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Study Information
Study Attribute Value
CEBS Accession Number: 002-01179-0021-0000-3
Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: 1746-01-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 163229_SCE
Study Result: Not a Valid Test


Table Instructions and Notes:

Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.


Detailed Sister Chromatid Exchange Data (Trial 1)
Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Trial Result
02/03/1988 Bone Marrow 23 Male Mouse B6C3F1 IP/IJ x 1,  23 hour Negative

Test Group Dose
(ug/kg)		 Animal
Number		 No.
Cells		 SCE / Cell
Mean ± SEM
Vehicle Control Corn Oil 
 0         
 7266 25 5.67 ± 0.533
    7267 25 4.76 ± 0.552
    7268 25 7.92 ± 1.180
    7269 25 8.20 ± 1.143
Average   6.64 ± 0.844
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
250         
 7231 25 3.88 ± 0.377
    7232 25 3.94 ± 0.444
    7233 25 3.91 ± 0.499
    7234 25 6.19 ± 0.672
Average   4.48 ± 0.569
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
500         
 7236 25 6.33 ± 0.905
    7237 25 6.15 ± 0.528
    7238 25 3.21 ± 0.402
    7239 25 3.73 ± 0.315
Average   4.86 ± 0.808
 
Test Chemical 2,3,7,8-Tetrachlorodibenzo-p-dioxin 
1000         
 7241 25 5.17 ± 0.418
    7242 25 5.78 ± 0.700
    7243 25 3.31 ± 0.374
    7244 25 4.29 ± 0.433
Average   4.64 ± 0.538
 
Positive Control Dimethylbenzanthracene 
2.5       
 7271 25 5.76 ± 0.459
    7272 25 4.79 ± 0.435
    7273 25 5.56 ± 0.538
    7274 25 4.58 ± 0.499
Average   5.17 ± 0.287
 

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed