COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0010-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 166234_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/26/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 246071 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246145 50 3 2 0 0 0 1 0 6 0.12 0.08 12.00 8.00
    246160 50 3 1 0 0 0 0 0 4 0.08 0.06 4.00 4.00
    246180 50 9 3 0 0 0 1 0 13 0.26 0.20 18.00 16.00
    246188 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    246193 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 4.00
    246198 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246204 50 1 1 0 0 0 1 0 3 0.06 0.04 8.00 6.00
    246241 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    246254 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
Average         3.0 1.9 0.0 0.0 0.0 0.4 0.0 5.3 0.11 0.07 7.50 6.00
± SEM                         0.03 0.02 2.23 1.60
 
Test Chemical Aroclor 1254 
1250         
 246119 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246130 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    246138 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246150 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    246154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246162 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246168 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246199 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246231 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 2.00
    246256 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 0.75 1.00
± SEM                         0.01 0.01 0.53 0.53
 
Test Chemical Aroclor 1254 
2500         
 246137 50 1 1 0 0 0 1 0 3 0.06 0.04 4.00 4.00
    246151 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    246159 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    246169 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    246184 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246232 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246238 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246243 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246257 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    246260 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
Average         0.6 0.5 0.0 0.0 0.0 0.1 0.0 1.3 0.03 0.02 1.25 1.50
± SEM                         0.01 0.01 0.65 0.63
 
Test Chemical Aroclor 1254 
5000         
 246068 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    246144 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246153 50 3 2 0 0 0 0 0 5 0.10 0.06 12.00 8.00
    246167 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246177 50 4 0 0 0 0 0 0 4 0.08 0.08 0.00 8.00
    246194 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246214 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246218 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    246228 50 5 1 0 0 0 0 0 6 0.12 0.10 8.00 8.00
    246234 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
Average         1.9 0.8 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.04 3.25 3.75
± SEM                         0.02 0.01 1.60 1.33
 
Vehicle Control No Stressor 
 0         
 246120 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246124 50 2 0 0 0 0 0 0 2 0.04 0.04 0.00 4.00
    246143 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    246170 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246173 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246176 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246186 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246224 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    246240 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 0.57 0.57
± SEM                         0.01 0.01 0.37 0.57
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation