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Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0010-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 166234_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/06/1991 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 266034 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266043 50 3 4 0 0 0 1 0 8 0.16 0.08 10.00 6.00
    266098 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    266211 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    266212 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    266216 50 0 6 0 0 0 0 0 6 0.12 0.00 10.00 0.00
    266219 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    266230 50 2 5 0 0 0 0 0 7 0.14 0.04 12.00 4.00
    266236 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266249 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.5 3.3 0.0 0.0 0.0 0.1 0.0 4.9 0.10 0.03 8.00 3.00
± SEM                         0.02 0.01 1.41 1.07
 
Test Chemical Aroclor 1254 
1250         
 266073 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266090 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266099 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    266126 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266145 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    266161 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    266162 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266210 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    266218 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    266222 50 1 2 0 1 0 0 0 4 0.08 0.02 8.00 2.00
Average         1.3 1.3 0.0 0.1 0.0 0.0 0.0 2.6 0.05 0.03 3.50 2.50
± SEM                         0.01 0.01 1.24 0.91
 
Test Chemical Aroclor 1254 
2500         
 266055 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266080 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    266117 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266147 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    266167 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    266225 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266228 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266234 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266237 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266246 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.6 0.9 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 2.75 1.25
± SEM                         0.01 0.01 1.13 0.65
 
Test Chemical Aroclor 1254 
5000         
 266070 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266094 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266130 50 0 0 0 1 0 0 0 1 0.02 0.00 2.00 0.00
    266135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266143 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    266163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266190 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266201 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    266226 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266248 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.5 0.0 0.1 0.0 0.0 0.0 0.8 0.02 0.00 1.25 0.25
± SEM                         0.01 0.00 0.75 0.25
 
Vehicle Control No Stressor 
 0         
 266056 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    266092 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    266183 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    266184 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    266192 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    266217 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    266220 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    266238 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    266245 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.8 0.1 0.0 0.0 0.0 0.0 2.3 0.05 0.01 4.00 0.89
± SEM                         0.01 0.01 0.91 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation