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Study Information
Study Attribute Value
CEBS Accession Number: 002-01666-0010-0000-2
Chemical Name: Aroclor 1254
CASRN: 11097-69-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 166234_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/20/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 375001 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375003 50 5 5 1 0 0 0 3 14 0.28 0.18 20.00 16.00
    375004 50 9 11 0 1 0 0 0 21 0.42 0.18 22.00 14.00
    375005 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
    375031 50 7 9 0 0 0 0 1 17 0.34 0.16 26.00 14.00
    375059 50 4 5 1 2 0 0 0 12 0.24 0.10 20.00 10.00
    375066 50 4 3 0 0 0 0 1 8 0.16 0.10 12.00 10.00
    375105 50 11 8 0 0 0 0 2 21 0.42 0.26 26.00 14.00
    375111 50 8 8 0 0 0 0 0 16 0.32 0.16 20.00 16.00
    375192 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         6.3 6.5 0.3 0.4 0.0 0.0 0.9 14.3 0.29 0.15 19.50 12.25
± SEM                         0.04 0.02 2.06 1.44
 
Positive Control Dimethylbenzanthracene 
200         
 375008 50 6 3 0 0 0 1 0 10 0.20 0.14 20.00 14.00
    375019 50 8 2 3 0 0 2 0 15 0.30 0.26 24.00 22.00
    375045 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375050 50 9 10 0 1 0 3 0 23 0.46 0.24 28.00 18.00
    375100 50 3 4 0 0 0 0 0 7 0.14 0.06 10.00 6.00
    375112 50 5 3 0 0 0 1 3 12 0.24 0.18 22.00 16.00
    375124 50 11 10 1 0 0 7 2 31 0.62 0.42 34.00 24.00
    375140 50 11 7 0 1 0 1 2 22 0.44 0.28 28.00 16.00
    375174 50 4 4 0 0 0 0 0 8 0.16 0.08 12.00 8.00
    375190 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         7.1 5.4 0.5 0.3 0.0 1.9 0.9 16.0 0.32 0.21 22.25 15.50
± SEM                         0.06 0.04 2.89 2.20
 
Test Chemical Aroclor 1254 
1250         
 375011 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    375013 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375018 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    375040 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    375056 50 1 4 0 0 0 0 0 5 0.10 0.02 10.00 2.00
    375070 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375077 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375079 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375098 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375189 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 1.0 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.01 3.00 1.00
± SEM                         0.01 0.01 1.36 0.53
 
Test Chemical Aroclor 1254 
2500         
 375006 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375009 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    375020 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    375046 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    375065 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    375117 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375155 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    375160 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375187 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    375198 50 2 3 1 0 0 0 0 6 0.12 0.06 10.00 6.00
Average         1.0 1.1 0.1 0.0 0.0 0.0 0.0 2.3 0.05 0.02 3.75 2.25
± SEM                         0.01 0.01 1.16 0.70
 
Test Chemical Aroclor 1254 
5000         
 375007 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    375014 50 1 3 1 0 0 0 0 5 0.10 0.04 6.00 4.00
    375025 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375051 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    375064 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375085 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    375121 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    375147 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    375148 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    375149 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.5 1.6 0.1 0.0 0.0 0.0 0.0 2.3 0.05 0.01 3.50 1.25
± SEM                         0.01 0.01 0.63 0.65
 
Vehicle Control No Stressor 
 0         
 375048 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375054 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375062 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375074 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    375078 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    375106 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375116 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375171 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375185 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    375188 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 1.24 0.76
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation