| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02670-0012-0000-0 |
| Chemical Name: | Phenol |
| CASRN: | 108-95-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 170681_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/13/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3351 | 25 | 5.22 | ± | 0.516 |
| 3353 | 25 | 6.65 | ± | 0.503 | |||
| 3354 | 25 | 4.88 | ± | 0.518 | |||
| 3355 | 25 | 4.98 | ± | 0.487 | |||
| Average | 5.43 | ± | 0.412 | ||||
| Test Chemical | Phenol |
75 |
3321 | 25 | 3.11 | ± | 0.434 |
| 3322 | 25 | 5.94 | ± | 0.611 | |||
| 3323 | 25 | 5.14 | ± | 0.470 | |||
| 3324 | 25 | 5.13 | ± | 0.469 | |||
| Average | 4.84 | ± | 0.603 | ||||
| Test Chemical | Phenol |
150 |
3326 | 25 | 4.29 | ± | 0.500 |
| 3327 | 25 | 4.92 | ± | 0.446 | |||
| 3328 | 25 | 3.72 | ± | 0.521 | |||
| 3329 | 25 | 3.41 | ± | 0.388 | |||
| Average | 4.08 | ± | 0.333 | ||||
| Test Chemical | Phenol |
300 |
3331 | 25 | 6.39 | ± | 0.615 |
| 3332 | 25 | 5.11 | ± | 0.539 | |||
| 3333 | 25 | 4.52 | ± | 0.411 | |||
| 3334 | 25 | 4.69 | ± | 0.444 | |||
| Average | 5.18 | ± | 0.423 | ||||
| Positive Control | Mitomycin-C |
0.5 |
3356 | 25 | 9.34 | ± | 0.799 |
| 3357 | 25 | 9.81 | ± | 0.947 | |||
| 3358 | 25 | 10.04 | ± | 0.742 | |||
| 3359 | 25 | 7.12 | ± | 0.473 | |||
| Average | 9.08 | ± | 0.669 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed