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Study Information
Study Attribute Value
CEBS Accession Number: 002-01265-0006-0000-2
Chemical Name: 2-Acetylaminofluorene
CASRN: 53-96-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 172752_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/28/1983 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical 2-Acetylaminofluorene 
250         
 696 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    700 50 3 4 0 0 0 0 3 10 0.20 0.12 10.00 6.00
    713 50 0 2 0 1 0 0 6 9 0.18 0.12 6.00 0.00
    869 50 2 4 0 0 0 0 0 6 0.12 0.04 10.00 4.00
    884 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
    885 50 3 4 0 0 0 0 0 7 0.14 0.06 10.00 6.00
    889 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    892 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         2.8 2.6 0.0 0.1 0.0 0.0 1.1 6.6 0.13 0.08 9.50 5.50
± SEM                         0.02 0.01 1.24 1.24
 
Test Chemical 2-Acetylaminofluorene 
500         
 695 50 0 3 0 0 0 0 2 5 0.10 0.04 6.00 0.00
    701 50 3 6 0 0 0 0 2 11 0.22 0.10 16.00 6.00
    703 50 1 0 0 0 0 0 4 5 0.10 0.10 2.00 2.00
    705 50 2 5 0 0 0 0 6 13 0.26 0.16 14.00 4.00
    708 50 0 1 0 0 0 0 6 7 0.14 0.12 2.00 0.00
    712 50 0 2 1 0 0 0 1 4 0.08 0.04 6.00 2.00
    715 50 0 0 0 0 1 0 1 2 0.04 0.04 2.00 2.00
    716 50 4 7 0 0 0 0 6 17 0.34 0.20 18.00 8.00
Average         1.3 3.0 0.1 0.0 0.1 0.0 3.5 8.0 0.16 0.10 8.25 3.00
± SEM                         0.04 0.02 2.37 1.00
 
Test Chemical 2-Acetylaminofluorene 
1000         
 694 50 1 8 0 0 0 0 4 13 0.26 0.10 16.00 2.00
    698 50 4 0 1 0 0 0 5 10 0.20 0.20 10.00 10.00
    707 50 2 3 0 0 0 0 6 11 0.22 0.16 10.00 4.00
    710 50 1 6 0 0 0 0 2 9 0.18 0.06 8.00 2.00
    714 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 4.00
    718 50 4 1 0 0 0 0 12 17 0.34 0.32 8.00 6.00
    724 50 1 2 0 0 0 0 1 4 0.08 0.04 6.00 2.00
    726 50 6 7 0 0 0 0 2 15 0.30 0.16 22.00 10.00
Average         2.8 4.0 0.1 0.0 0.0 0.0 4.0 10.9 0.22 0.14 11.50 5.00
± SEM                         0.03 0.03 1.84 1.20
 
Vehicle Control No Stressor 
 0         
 689 50 0 4 0 0 0 0 0 4 0.08 0.00 4.00 0.00
    709 50 1 2 0 0 0 0 2 5 0.10 0.06 4.00 2.00
    711 50 0 3 0 0 0 0 1 4 0.08 0.02 6.00 0.00
    721 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    723 50 1 1 0 0 0 0 5 7 0.14 0.12 4.00 2.00
    870 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    873 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    882 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.4 0.0 0.0 0.0 0.0 1.0 3.0 0.06 0.03 3.00 1.00
± SEM                         0.02 0.02 0.93 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation