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Study Information
Study Attribute Value
CEBS Accession Number: 002-01265-0006-0000-2
Chemical Name: 2-Acetylaminofluorene
CASRN: 53-96-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 172752_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/29/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5824 50 21 2 1 0 0 0 0 24 0.48 0.44 20.00 18.00
    5828 50 57 8 0 0 0 0 0 65 1.30 1.14 38.00 32.00
    5831 50 4 7 0 0 0 0 0 11 0.22 0.08 18.00 8.00
    5834 50 46 7 0 0 0 0 0 53 1.06 0.92 30.00 24.00
    5840 50 46 13 1 0 0 0 0 60 1.20 0.94 42.00 30.00
    5849 50 26 7 0 0 0 0 0 33 0.66 0.52 22.00 14.00
    5860 50 50 10 1 1 0 0 1 63 1.26 1.04 42.00 36.00
    5876 50 84 9 0 0 0 0 0 93 1.86 1.68 48.00 38.00
Average         41.8 7.9 0.4 0.1 0.0 0.0 0.1 50.3 1.01 0.85 32.50 25.00
± SEM                         0.19 0.17 4.08 3.84
 
Test Chemical 2-Acetylaminofluorene 
200         
 5813 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5815 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5817 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5822 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5827 50 0 1 0 0 0 1 0 2 0.04 0.02 4.00 2.00
    5837 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    5839 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5845 50 1 0 0 0 0 0 0 1 0.02 0.02 4.00 4.00
Average         0.5 0.8 0.0 0.0 0.0 0.1 0.1 1.5 0.03 0.02 3.00 1.50
± SEM                         0.01 0.00 0.93 0.50
 
Test Chemical 2-Acetylaminofluorene 
400         
 5816 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5829 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5838 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5841 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5842 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5843 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5846 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    5847 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.6 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.50 1.25
± SEM                         0.01 0.01 0.91 0.53
 
Test Chemical 2-Acetylaminofluorene 
800         
 5819 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5833 50 5 2 0 0 0 0 0 7 0.14 0.10 14.00 10.00
    5836 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6083 50 20 8 1 0 0 1 6 36 0.72 0.56 58.00 44.00
    6085 50 20 4 0 0 3 1 20 48 0.96 0.88 104.00 96.00
    6088 50 9 2 0 0 2 0 13 26 0.52 0.48 60.00 56.00
    6090 50 31 4 1 0 1 0 20 57 1.14 1.06 108.00 102.00
    6093 50 12 0 1 0 15 0 27 55 1.10 1.10 118.00 118.00
Average         12.4 2.5 0.4 0.0 2.6 0.3 10.8 28.9 0.58 0.53 58.25 53.75
± SEM                         0.17 0.16 17.13 16.70
 
Vehicle Control No Stressor 
 0         
 5812 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5818 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    5820 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5835 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5854 50 3 2 1 0 0 0 0 6 0.12 0.08 8.00 6.00
    5870 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5885 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.7 0.9 0.1 0.0 0.0 0.0 0.0 2.7 0.05 0.04 4.86 3.43
± SEM                         0.02 0.01 1.22 1.04
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation