| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01265-0005-0000-1 |
| Chemical Name: | 2-Acetylaminofluorene |
| CASRN: | 53-96-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 172752_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/28/1983 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | IP/IJ x 1, 17 hour |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
689 | 25 | 4.74 | ± | 0.242 |
| 711 | 25 | 4.15 | ± | 0.348 | |||
| 723 | 25 | 5.61 | ± | 0.564 | |||
| 725 | 25 | 3.65 | ± | 0.372 | |||
| Average | 4.54 | ± | 0.421 | ||||
| Test Chemical | 2-Acetylaminofluorene |
250 |
690 | 25 | 5.10 | ± | 0.487 |
| 693 | 25 | 4.47 | ± | 0.364 | |||
| 702 | 25 | 4.87 | ± | 0.346 | |||
| 717 | 25 | 4.19 | ± | 0.332 | |||
| Average | 4.66 | ± | 0.203 | ||||
| Test Chemical | 2-Acetylaminofluorene |
500 |
701 | 25 | 9.60 | ± | 0.894 |
| 705 | 25 | 12.29 | ± | 0.691 | |||
| 715 | 25 | 8.49 | ± | 0.770 | |||
| 716 | 25 | 13.39 | ± | 0.905 | |||
| Average | 10.97 | ± | 1.141 | ||||
| Test Chemical | 2-Acetylaminofluorene |
1000 |
698 | 25 | 16.11 | ± | 0.984 |
| 710 | 25 | 12.44 | ± | 0.984 | |||
| 714 | 25 | 15.66 | ± | 1.204 | |||
| 718 | 25 | 16.44 | ± | 0.543 | |||
| Average | 15.16 | ± | 0.922 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed