| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01698-0009-0000-5 |
| Chemical Name: | Benzo(a)pyrene |
| CASRN: | 50-32-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 181345_CA |
| Study Result: | Positive (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 06/20/1983 | Bone Marrow | 18 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 18 hour | Positive (Nonstandard Protocol) |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Test Chemical | Benzo(a)pyrene |
37.5 |
1096 | 100 | 8 | 3 | 2 | 0 | 0 | 0 | 1 | 14 | 0.14 | 0.11 | 9.00 | 7.00 |
| 1097 | 100 | 4 | 2 | 0 | 0 | 0 | 0 | 4 | 10 | 0.10 | 0.08 | 5.00 | 4.00 | |||
| 1098 | 100 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 11 | 0.11 | 0.11 | 7.00 | 7.00 | |||
| 1100 | 100 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0.05 | 0.05 | 5.00 | 5.00 | |||
| Average | 6.8 | 1.3 | 0.5 | 0.0 | 0.0 | 0.0 | 1.5 | 10.0 | 0.10 | 0.09 | 6.50 | 5.75 | ||||
| ± SEM | 0.02 | 0.01 | 0.96 | 0.75 | ||||||||||||
| Test Chemical | Benzo(a)pyrene |
75 |
1102 | 100 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.01 | 0.01 | 1.00 | 1.00 |
| 1103 | 100 | 5 | 0 | 1 | 0 | 0 | 0 | 2 | 8 | 0.08 | 0.08 | 7.00 | 7.00 | |||
| 1104 | 100 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 6 | 0.06 | 0.03 | 4.00 | 2.00 | |||
| 1105 | 100 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 5 | 0.05 | 0.04 | 5.00 | 4.00 | |||
| Average | 3.3 | 0.8 | 0.3 | 0.3 | 0.0 | 0.0 | 0.5 | 5.0 | 0.05 | 0.04 | 4.25 | 3.50 | ||||
| ± SEM | 0.01 | 0.01 | 1.25 | 1.32 | ||||||||||||
| Test Chemical | Benzo(a)pyrene |
150 |
1106 | 100 | 3 | 5 | 0 | 0 | 0 | 0 | 3 | 11 | 0.11 | 0.06 | 8.00 | 6.00 |
| 1107 | 100 | 10 | 3 | 0 | 0 | 0 | 0 | 0 | 13 | 0.13 | 0.10 | 9.00 | 7.00 | |||
| 1109 | 100 | 3 | 2 | 1 | 0 | 0 | 0 | 1 | 7 | 0.07 | 0.05 | 7.00 | 5.00 | |||
| 1110 | 100 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| Average | 4.5 | 2.5 | 0.3 | 0.0 | 0.0 | 0.0 | 1.0 | 8.3 | 0.08 | 0.06 | 6.50 | 5.00 | ||||
| ± SEM | 0.02 | 0.02 | 1.55 | 1.08 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
1131 | 100 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 7 | 0.07 | 0.04 | 6.00 | 3.00 |
| 1132 | 100 | 11 | 0 | 0 | 0 | 0 | 0 | 2 | 13 | 0.13 | 0.13 | 7.00 | 7.00 | |||
| 1134 | 100 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.05 | 0.04 | 4.00 | 4.00 | |||
| 1135 | 100 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0.08 | 0.08 | 6.00 | 6.00 | |||
| Average | 6.8 | 1.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.5 | 8.3 | 0.08 | 0.07 | 5.75 | 5.00 | ||||
| ± SEM | 0.02 | 0.02 | 0.63 | 0.91 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation