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Study Information
Study Attribute Value
CEBS Accession Number: 002-01824-0012-0000-0
Chemical Name: Caprolactam
CASRN: 105-60-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 201538_CA
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/20/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical Caprolactam 
175         
 1378 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1379 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1380 50 2 0 1 0 0 0 0 3 0.06 0.06 4.00 4.00
    1381 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1382 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1383 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1384 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1385 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.5 0.1 0.3 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.50 1.25
± SEM                         0.01 0.01 0.63 0.65
 
Test Chemical Caprolactam 
350         
 1386 50 7 0 0 0 0 0 0 7 0.14 0.14 10.00 10.00
    1387 50 1 1 1 0 0 0 0 3 0.06 0.04 4.00 4.00
    1388 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1389 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1390 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1391 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    1392 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1393 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.8 0.4 0.3 0.0 0.0 0.0 0.0 2.4 0.05 0.04 4.00 3.50
± SEM                         0.01 0.02 0.93 1.05
 
Test Chemical Caprolactam 
700         
 1394 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1395 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1396 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    1397 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    1398 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    1399 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1400 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1401 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.5 0.4 0.1 0.0 0.0 0.0 0.0 2.0 0.04 0.03 4.00 3.25
± SEM                         0.01 0.01 1.13 0.84
 
Vehicle Control No Stressor 
 0         
 1370 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1371 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1372 50 2 0 1 0 0 0 0 3 0.06 0.06 4.00 4.00
    1373 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1374 50 4 0 0 0 0 0 0 4 0.08 0.08 6.00 6.00
    1375 50 2 1 2 0 0 0 1 6 0.12 0.10 8.00 6.00
    1376 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1377 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.4 0.1 0.4 0.0 0.0 0.0 0.1 2.0 0.04 0.04 3.00 2.75
± SEM                         0.02 0.01 1.07 0.92
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation