| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01824-0011-0000-9 |
| Chemical Name: | Caprolactam |
| CASRN: | 105-60-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 201538_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/14/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1366 | 25 | 3.80 | ± | 0.404 |
| 1367 | 25 | 5.96 | ± | 0.682 | |||
| 1368 | 25 | 4.13 | ± | 0.424 | |||
| 1369 | 25 | 4.54 | ± | 0.487 | |||
| Average | 4.61 | ± | 0.475 | ||||
| Test Chemical | Caprolactam |
175 |
1333 | 25 | 4.33 | ± | 0.426 |
| 1334 | 25 | 4.44 | ± | 0.428 | |||
| 1335 | 25 | 4.09 | ± | 0.513 | |||
| 1336 | 25 | 4.65 | ± | 0.468 | |||
| Average | 4.38 | ± | 0.116 | ||||
| Test Chemical | Caprolactam |
350 |
1337 | 25 | 4.84 | ± | 0.468 |
| 1338 | 25 | 3.63 | ± | 0.424 | |||
| 1339 | 25 | 4.68 | ± | 0.573 | |||
| 1340 | 25 | 4.85 | ± | 0.588 | |||
| Average | 4.50 | ± | 0.292 | ||||
| Test Chemical | Caprolactam |
700 |
1341 | 25 | 3.82 | ± | 0.456 |
| 1342 | 25 | 3.89 | ± | 0.460 | |||
| 1343 | 25 | 4.54 | ± | 0.552 | |||
| 1344 | 25 | 5.38 | ± | 0.787 | |||
| Average | 4.41 | ± | 0.362 | ||||
| Positive Control | Dimethylbenzanthracene |
5 |
1325 | 25 | 9.33 | ± | 0.752 |
| 1326 | 25 | 10.33 | ± | 0.928 | |||
| 1327 | 25 | 10.93 | ± | 0.971 | |||
| 1328 | 25 | 12.00 | ± | 1.333 | |||
| Average | 10.64 | ± | 0.557 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed