| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0011-0000-0 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 208472_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/03/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3200 | 25 | 6.25 | ± | 0.601 |
| 3205 | 25 | 6.62 | ± | 0.578 | |||
| 3207 | 25 | 5.29 | ± | 0.478 | |||
| 3212 | 25 | 6.06 | ± | 0.527 | |||
| Average | 6.06 | ± | 0.280 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
25 |
3204 | 24 | 4.12 | ± | 0.465 |
| 3210 | 25 | 4.83 | ± | 0.507 | |||
| 3219 | 25 | 5.06 | ± | 0.549 | |||
| 3223 | 25 | 5.12 | ± | 0.543 | |||
| Average | 4.79 | ± | 0.228 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
50 |
3202 | 25 | 6.64 | ± | 0.531 |
| 3211 | 25 | 5.51 | ± | 0.429 | |||
| 3220 | 25 | 6.21 | ± | 0.683 | |||
| 3227 | 25 | 5.27 | ± | 0.351 | |||
| Average | 5.92 | ± | 0.316 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
100 |
3198 | 25 | 5.22 | ± | 0.422 |
| 3209 | 25 | 6.88 | ± | 0.558 | |||
| 3213 | 25 | 4.41 | ± | 0.368 | |||
| 3216 | 25 | 4.54 | ± | 0.446 | |||
| Average | 5.26 | ± | 0.567 | ||||
| Positive Control | Mitomycin-C |
0.5 |
3199 | 25 | 10.93 | ± | 0.561 |
| 3208 | 25 | 13.42 | ± | 0.705 | |||
| 3214 | 25 | 12.14 | ± | 0.788 | |||
| 3218 | 25 | 10.75 | ± | 0.857 | |||
| Average | 11.81 | ± | 0.620 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed