| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01311-0011-0000-0 |
| Chemical Name: | 2-Chloroethanol (ethylene chlorohydrin) |
| CASRN: | 107-07-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 208472_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/18/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
5965 | 25 | 3.36 | ± | 0.347 |
| 5978 | 25 | 6.46 | ± | 0.654 | |||
| 5992 | 24 | 5.70 | ± | 0.570 | |||
| Average | 5.17 | ± | 0.932 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
25 |
5971 | 23 | 3.79 | ± | 0.451 |
| 5976 | 25 | 4.59 | ± | 0.413 | |||
| 5984 | 25 | 4.88 | ± | 0.424 | |||
| 5993 | 25 | 4.67 | ± | 0.465 | |||
| Average | 4.50 | ± | 0.237 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
50 |
5950 | 25 | 4.99 | ± | 0.506 |
| 5980 | 24 | 4.22 | ± | 0.386 | |||
| 5995 | 24 | 3.29 | ± | 0.444 | |||
| 6004 | 25 | 4.06 | ± | 0.388 | |||
| Average | 4.14 | ± | 0.349 | ||||
| Test Chemical | 2-Chloroethanol (ethylene chlorohydrin) |
100 |
5955 | 25 | 7.97 | ± | 0.531 |
| 5964 | 25 | 4.37 | ± | 0.379 | |||
| 5969 | 25 | 7.67 | ± | 0.484 | |||
| 6011 | 25 | 4.84 | ± | 0.517 | |||
| Average | 6.21 | ± | 0.935 | ||||
| Positive Control | Mitomycin-C |
0.5 |
5946 | 24 | 4.42 | ± | 0.421 |
| 5975 | 24 | 3.83 | ± | 0.360 | |||
| 6000 | 23 | 3.80 | ± | 0.477 | |||
| 6017 | 25 | 3.91 | ± | 0.345 | |||
| Average | 4.00 | ± | 0.145 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed