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Study Information
Study Attribute Value
CEBS Accession Number: 002-01076-0014-0000-1
Chemical Name: 1,3-Dichloropropene (Telone II)
CASRN: 542-75-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 208737_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
08/03/1987 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6315 50 13 33 0 2 0 0 0 48 0.96 0.26 52.00 20.00
    6316 50 8 17 3 0 0 0 0 28 0.56 0.22 36.00 20.00
    6317 50 10 11 0 0 0 0 0 21 0.42 0.20 22.00 14.00
    6318 50 7 21 0 0 0 0 1 29 0.58 0.16 32.00 12.00
    6319 50 15 48 0 0 0 0 0 63 1.26 0.30 46.00 20.00
    6320 50 1 5 0 0 0 0 0 6 0.12 0.02 10.00 2.00
    6321 50 9 16 0 0 0 0 0 25 0.50 0.18 34.00 16.00
    6322 50 6 18 1 0 0 0 0 25 0.50 0.14 26.00 12.00
Average         8.6 21.1 0.5 0.3 0.0 0.0 0.1 30.6 0.61 0.19 32.25 14.50
± SEM                         0.12 0.03 4.70 2.16
 
Test Chemical 1,3-Dichloropropene (Telone II) 
50         
 6275 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6276 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6277 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6278 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    6279 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6280 50 0 3 0 2 0 0 0 5 0.10 0.00 8.00 0.00
    6281 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6282 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
Average         0.6 1.0 0.0 0.3 0.0 0.0 0.0 1.9 0.04 0.01 3.25 1.25
± SEM                         0.01 0.01 0.92 0.53
 
Test Chemical 1,3-Dichloropropene (Telone II) 
100         
 6285 50 2 5 0 0 0 0 0 7 0.14 0.04 12.00 4.00
    6286 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6287 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6288 50 0 1 1 0 0 0 0 2 0.04 0.02 4.00 2.00
    6289 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6290 50 3 5 0 0 0 0 0 8 0.16 0.06 12.00 4.00
    6291 50 2 5 0 0 0 0 0 7 0.14 0.04 10.00 4.00
    6292 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.6 2.1 0.1 0.0 0.0 0.0 0.0 3.9 0.08 0.04 6.50 3.25
± SEM                         0.02 0.01 1.45 0.37
 
Test Chemical 1,3-Dichloropropene (Telone II) 
200         
 6295 50 4 4 0 0 0 0 0 8 0.16 0.08 14.00 8.00
    6296 50 6 1 0 0 0 0 0 7 0.14 0.12 8.00 6.00
    6297 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 4.00
    6298 50 5 2 0 0 0 0 0 7 0.14 0.10 8.00 4.00
    6299 50 8 6 1 0 0 0 0 15 0.30 0.18 20.00 10.00
    6300 50 3 4 0 0 0 0 0 7 0.14 0.06 14.00 6.00
    6301 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    6302 50 4 4 1 0 0 0 0 9 0.18 0.10 12.00 8.00
Average         4.1 3.4 0.3 0.0 0.0 0.0 0.0 7.8 0.16 0.09 11.50 5.75
± SEM                         0.02 0.02 1.55 1.10
 
Vehicle Control No Stressor 
 0         
 6305 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6306 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    6307 50 1 6 0 0 0 0 0 7 0.14 0.02 8.00 2.00
    6308 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    6309 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    6310 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    6311 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6312 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.0 1.9 0.0 0.0 0.0 0.0 0.0 2.9 0.06 0.02 4.50 2.00
± SEM                         0.02 0.01 1.18 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation