| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01076-0013-0000-0 |
| Chemical Name: | 1,3-Dichloropropene (Telone II) |
| CASRN: | 542-75-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 208737_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/13/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
4955 | 25 | 8.78 | ± | 0.642 |
| 4956 | 25 | 5.63 | ± | 0.425 | |||
| 4957 | 25 | 4.85 | ± | 0.580 | |||
| 4958 | 25 | 5.86 | ± | 0.565 | |||
| Average | 6.28 | ± | 0.860 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
50 |
4941 | 25 | 5.89 | ± | 0.572 |
| 4942 | 25 | 5.76 | ± | 0.453 | |||
| 4943 | 25 | 4.30 | ± | 0.394 | |||
| 4944 | 25 | 4.66 | ± | 0.425 | |||
| Average | 5.15 | ± | 0.396 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
100 |
4946 | 25 | 4.18 | ± | 0.420 |
| 4947 | 25 | 4.87 | ± | 0.412 | |||
| 4948 | 25 | 4.38 | ± | 0.421 | |||
| 4949 | 25 | 6.23 | ± | 0.772 | |||
| Average | 4.92 | ± | 0.462 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
200 |
4952 | 25 | 6.27 | ± | 0.527 |
| 4953 | 25 | 6.77 | ± | 0.561 | |||
| 4954 | 25 | 7.18 | ± | 0.604 | |||
| Average | 6.74 | ± | 0.264 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
4960 | 25 | 9.40 | ± | 0.738 |
| 4962 | 25 | 9.72 | ± | 0.771 | |||
| 4963 | 25 | 8.37 | ± | 0.727 | |||
| 4964 | 25 | 9.68 | ± | 0.795 | |||
| Average | 9.29 | ± | 0.314 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed