| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01076-0013-0000-0 |
| Chemical Name: | 1,3-Dichloropropene (Telone II) |
| CASRN: | 542-75-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 208737_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/22/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Not a Valid Test |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7455 | 25 | 11.91 | ± | 1.340 |
| 7456 | 25 | 4.07 | ± | 0.363 | |||
| 7457 | 25 | 4.85 | ± | 0.669 | |||
| 7458 | 25 | 4.00 | ± | 0.465 | |||
| Average | 6.21 | ± | 1.911 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
50 |
7440 | 25 | 3.91 | ± | 0.440 |
| 7441 | 25 | 7.23 | ± | 0.873 | |||
| 7442 | 25 | 3.17 | ± | 0.377 | |||
| 7443 | 25 | 2.62 | ± | 0.419 | |||
| Average | 4.23 | ± | 1.034 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
100 |
7445 | 25 | 3.82 | ± | 0.537 |
| 7446 | 25 | 5.44 | ± | 0.633 | |||
| 7447 | 25 | 3.80 | ± | 0.412 | |||
| 7448 | 25 | 4.12 | ± | 0.476 | |||
| Average | 4.30 | ± | 0.389 | ||||
| Test Chemical | 1,3-Dichloropropene (Telone II) |
200 |
7450 | 25 | 3.61 | ± | 0.487 |
| 7451 | 25 | 4.08 | ± | 0.519 | |||
| 7452 | 25 | 4.91 | ± | 0.639 | |||
| 7454 | 25 | 2.56 | ± | 0.469 | |||
| Average | 3.79 | ± | 0.489 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7460 | 25 | 4.33 | ± | 0.429 |
| 7461 | 25 | 8.80 | ± | 0.676 | |||
| 7462 | 25 | 7.74 | ± | 0.929 | |||
| 7463 | 25 | 11.01 | ± | 0.738 | |||
| Average | 7.97 | ± | 1.391 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed