| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02208-0024-0000-0 |
| Chemical Name: | Glutaraldehyde |
| CASRN: | 111-30-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 212368_CA |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 07/08/1991 | Bone Marrow | 17 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 17 hour | Positive |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Positive Control | Mitomycin-C |
1 |
259116 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 259117 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259121 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259126 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259128 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259136 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| 259146 | 50 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.10 | 0.00 | 8.00 | |||
| 259150 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259157 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
| 259159 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| Average | 1.0 | 0.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.3 | 0.03 | 0.02 | 0.75 | 1.75 | ||||
| ± SEM | 0.01 | 0.01 | 0.53 | 0.96 | ||||||||||||
| Test Chemical | Glutaraldehyde |
15 |
259098 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 2.00 |
| 259099 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| 259111 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
| 259119 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259120 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259140 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259143 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259144 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259155 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259158 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 6.00 | 6.00 | |||
| Average | 0.6 | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.0 | 0.02 | 0.01 | 1.50 | 1.50 | ||||
| ± SEM | 0.01 | 0.01 | 0.82 | 0.73 | ||||||||||||
| Test Chemical | Glutaraldehyde |
30 |
259070 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 259101 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259103 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259104 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
| 259107 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259112 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259115 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259125 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259135 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259153 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| Average | 0.4 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.5 | 0.01 | 0.01 | 0.75 | 0.75 | ||||
| ± SEM | 0.01 | 0.01 | 0.75 | 0.53 | ||||||||||||
| Test Chemical | Glutaraldehyde |
60 |
259097 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 259102 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259105 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259108 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259127 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259130 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259132 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| 259137 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259149 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259151 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 0.00 | 2.00 | |||
| Average | 0.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | 0.01 | 0.01 | 0.00 | 0.75 | ||||
| ± SEM | 0.00 | 0.00 | 0.00 | 0.37 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
259100 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 |
| 259109 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259110 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259114 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259139 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259145 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259148 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259154 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259156 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 259160 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
| Average | 0.0 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.1 | 0.00 | 0.00 | 0.25 | 0.00 | ||||
| ± SEM | 0.00 | 0.00 | 0.25 | 0.00 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation