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Study Information
Study Attribute Value
CEBS Accession Number: 002-02208-0024-0000-0
Chemical Name: Glutaraldehyde
CASRN: 111-30-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 212368_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/10/1991 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 267031 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    267096 50 5 4 0 0 0 3 0 12 0.24 0.16 18.00 14.00
    267113 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267117 50 7 1 0 0 0 0 0 8 0.16 0.14 14.00 14.00
    267140 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267147 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    267166 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    267190 50 0 4 1 0 0 1 0 6 0.12 0.04 10.00 4.00
    267197 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267200 50 5 1 0 0 0 1 0 7 0.14 0.12 14.00 12.00
Average         2.6 1.8 0.1 0.0 0.0 0.6 0.0 5.1 0.10 0.07 9.00 6.50
± SEM                         0.03 0.02 2.14 2.06
 
Test Chemical Glutaraldehyde 
15         
 267069 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    267071 50 1 4 0 0 0 2 0 7 0.14 0.06 12.00 4.00
    267092 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    267098 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267120 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267143 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    267154 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267167 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    267168 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    267171 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.5 0.0 0.0 0.0 0.3 0.0 2.4 0.05 0.02 4.25 1.50
± SEM                         0.02 0.01 1.49 0.63
 
Test Chemical Glutaraldehyde 
30         
 267015 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267077 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    267082 50 1 8 0 2 0 0 0 11 0.22 0.02 22.00 2.00
    267110 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    267116 50 1 3 0 1 0 0 0 5 0.10 0.02 8.00 2.00
    267121 50 4 2 0 0 0 0 0 6 0.12 0.08 10.00 6.00
    267134 50 4 1 0 0 0 1 0 6 0.12 0.10 12.00 10.00
    267172 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267182 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267198 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.6 2.0 0.0 0.4 0.0 0.1 0.0 4.1 0.08 0.04 7.50 3.25
± SEM                         0.03 0.01 2.58 1.13
 
Test Chemical Glutaraldehyde 
50         
 267034 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267052 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267062 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267080 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    267081 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    267090 50 6 14 1 3 0 0 0 24 0.48 0.14 36.00 12.00
    267097 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267114 50 8 9 2 2 0 0 0 21 0.42 0.20 32.00 16.00
    267139 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    267195 50 3 8 0 1 0 1 0 13 0.26 0.08 20.00 8.00
Average         2.5 4.5 0.4 0.8 0.0 0.1 0.0 8.3 0.17 0.06 13.00 5.25
± SEM                         0.07 0.03 5.10 2.17
 
Test Chemical Glutaraldehyde 
60         
 267041 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267083 50 2 2 0 2 0 0 0 6 0.12 0.04 12.00 4.00
    267084 50 3 0 0 0 0 0 0 3 0.06 0.06 0.00 6.00
    267099 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    267119 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267126 50 1 1 0 2 0 0 0 4 0.08 0.02 8.00 2.00
    267129 50 5 7 0 1 0 1 0 14 0.28 0.12 22.00 12.00
    267152 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    267163 50 4 5 0 1 0 0 0 10 0.20 0.08 18.00 6.00
    267189 50 5 4 0 2 0 0 0 11 0.22 0.10 22.00 10.00
Average         2.9 2.5 0.0 1.0 0.0 0.1 0.0 6.5 0.13 0.06 11.00 5.75
± SEM                         0.03 0.01 3.18 1.28
 
Vehicle Control No Stressor 
 0         
 267005 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    267012 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    267023 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    267065 50 0 2 0 2 0 0 0 4 0.08 0.00 2.00 0.00
    267075 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    267086 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267146 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267174 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    267183 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    267187 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
Average         0.3 1.5 0.0 0.3 0.0 0.0 0.0 2.0 0.04 0.01 2.75 0.50
± SEM                         0.01 0.00 0.92 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation