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Study Information
Study Attribute Value
CEBS Accession Number: 002-02208-0024-0000-0
Chemical Name: Glutaraldehyde
CASRN: 111-30-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 212368_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/02/1993 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
2         
 374009 50 12 3 4 0 1 4 1 25 0.50 0.44 18.00 14.00
    374022 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374029 50 2 2 1 0 0 0 0 5 0.10 0.06 6.00 4.00
    374044 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    374086 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374106 50 2 1 0 0 0 0 1 4 0.08 0.06 8.00 6.00
    374107 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    374138 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    374155 50 7 3 0 0 0 0 1 11 0.22 0.16 16.00 14.00
    374157 50 7 2 0 0 0 2 0 11 0.22 0.18 12.00 10.00
Average         4.1 1.8 0.6 0.0 0.1 0.8 0.4 7.8 0.16 0.12 8.75 6.75
± SEM                         0.06 0.05 2.17 1.85
 
Test Chemical Glutaraldehyde 
15         
 374003 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374031 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374062 50 2 2 1 1 0 0 0 6 0.12 0.06 10.00 4.00
    374068 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374088 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374090 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    374121 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    374131 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374152 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374161 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.0 0.1 0.1 0.0 0.0 0.0 1.6 0.03 0.01 3.00 0.75
± SEM                         0.01 0.01 1.25 0.53
 
Test Chemical Glutaraldehyde 
30         
 374001 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374010 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374124 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374127 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    374140 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    374141 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374143 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374156 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374171 50 1 1 0 1 0 0 0 3 0.06 0.02 6.00 2.00
    374183 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.5 1.0 0.0 0.1 0.0 0.0 0.0 1.6 0.03 0.01 3.00 0.75
± SEM                         0.01 0.01 0.85 0.37
 
Test Chemical Glutaraldehyde 
50         
 374030 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    374070 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374076 50 2 6 0 2 0 0 0 10 0.20 0.04 16.00 4.00
    374078 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374134 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374144 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374154 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374160 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 2.00
    374163 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374187 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.3 0.0 0.3 0.0 0.0 0.0 1.9 0.04 0.01 3.00 0.75
± SEM                         0.02 0.01 2.00 0.53
 
Test Chemical Glutaraldehyde 
60         
 374017 50 0 4 0 2 0 0 0 6 0.12 0.00 10.00 0.00
    374027 50 3 3 1 0 0 0 0 7 0.14 0.08 12.00 8.00
    374050 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    374061 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374079 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    374125 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374181 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    374191 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374194 50 1 4 1 0 0 0 0 6 0.12 0.04 12.00 4.00
    374195 50 2 7 2 0 0 0 0 11 0.22 0.08 16.00 6.00
Average         1.1 3.0 0.5 0.3 0.0 0.0 0.0 4.9 0.10 0.03 8.25 3.00
± SEM                         0.02 0.01 1.87 1.07
 
Vehicle Control No Stressor 
 0         
 374008 50 0 1 0 1 0 0 0 2 0.04 0.00 2.00 0.00
    374012 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    374032 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374037 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374071 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    374073 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    374109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374114 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    374130 50 1 5 0 0 0 0 0 6 0.12 0.02 8.00 2.00
    374135 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 1.5 0.0 0.1 0.0 0.0 0.0 1.9 0.04 0.01 2.50 0.50
± SEM                         0.02 0.00 1.05 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation