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Study Information
Study Attribute Value
CEBS Accession Number: 002-01796-0013-0000-9
Chemical Name: C.I. Disperse yellow 3
CASRN: 2832-40-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 221078_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/14/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11889 50 16 7 0 0 0 0 0 23 0.46 0.32 26.00 22.00
    11902 50 14 2 0 0 0 0 0 16 0.32 0.28 24.00 22.00
    11926 50 5 3 0 0 0 0 0 8 0.16 0.10 12.00 8.00
    11939 50 10 2 0 0 0 0 0 12 0.24 0.20 16.00 16.00
    11942 50 18 5 1 0 0 0 0 24 0.48 0.38 28.00 20.00
    11966 50 17 1 1 0 0 0 0 19 0.38 0.36 16.00 14.00
    11972 50 13 3 0 0 0 0 0 16 0.32 0.26 12.00 8.00
    11990 50 11 2 0 0 0 0 0 13 0.26 0.22 8.00 4.00
Average         13.0 3.1 0.3 0.0 0.0 0.0 0.0 16.4 0.33 0.27 17.75 14.25
± SEM                         0.04 0.03 2.60 2.46
 
Test Chemical C.I. Disperse yellow 3 
450         
 11925 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11927 50 3 2 0 0 0 0 0 5 0.10 0.06 8.00 6.00
    11931 50 3 1 0 0 0 0 1 5 0.10 0.08 10.00 8.00
    11943 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11947 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11948 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11951 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11958 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.4 1.1 0.0 0.0 0.0 0.0 0.1 2.6 0.05 0.03 5.00 3.00
± SEM                         0.01 0.01 1.25 1.00
 
Test Chemical C.I. Disperse yellow 3 
900         
 11930 50 6 0 0 0 0 0 0 6 0.12 0.12 8.00 8.00
    11932 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 8.00
    11934 50 6 6 0 0 0 0 0 12 0.24 0.12 18.00 12.00
    11940 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11945 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11946 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11949 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11950 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         2.9 1.9 0.0 0.0 0.0 0.0 0.0 4.8 0.10 0.06 8.00 5.00
± SEM                         0.02 0.02 1.69 1.41
 
Test Chemical C.I. Disperse yellow 3 
1800         
 11922 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11923 50 6 0 0 0 0 0 0 6 0.12 0.12 10.00 10.00
    11929 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11936 50 1 4 0 0 0 0 0 5 0.10 0.02 6.00 2.00
    11937 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11952 50 0 2 1 0 0 0 0 3 0.06 0.02 6.00 2.00
    11957 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    11959 50 6 2 1 0 0 0 0 9 0.18 0.14 12.00 10.00
Average         1.6 2.1 0.3 0.0 0.0 0.0 0.0 4.0 0.08 0.04 6.50 3.00
± SEM                         0.02 0.02 1.18 1.56
 
Vehicle Control No Stressor 
 0         
 11894 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11905 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11924 50 4 4 0 0 0 0 0 8 0.16 0.08 14.00 6.00
    11935 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11941 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    11944 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11970 50 0 1 0 0 0 0 0 1 0.02 0.00 4.00 2.00
    11982 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.0 2.0 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.02 5.75 2.00
± SEM                         0.02 0.01 1.28 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation