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Study Information
Study Attribute Value
CEBS Accession Number: 002-01796-0013-0000-9
Chemical Name: C.I. Disperse yellow 3
CASRN: 2832-40-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 221078_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/27/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 12255 50 4 2 0 0 0 0 3 9 0.18 0.14 12.00 8.00
    12271 50 3 4 0 0 0 0 1 8 0.16 0.08 16.00 8.00
    12272 50 6 4 0 0 0 0 1 11 0.22 0.14 14.00 8.00
    12281 50 4 3 1 0 0 0 1 9 0.18 0.12 16.00 10.00
    12290 50 6 9 0 0 0 0 1 16 0.32 0.14 22.00 12.00
    12301 50 5 5 0 0 0 0 0 10 0.20 0.10 20.00 12.00
    12303 50 2 4 0 0 0 0 1 7 0.14 0.06 8.00 4.00
    12307 50 2 0 0 0 0 0 2 4 0.08 0.08 6.00 6.00
Average         4.0 3.9 0.1 0.0 0.0 0.0 1.3 9.3 0.19 0.11 14.25 8.50
± SEM                         0.02 0.01 1.94 0.98
 
Test Chemical C.I. Disperse yellow 3 
450         
 12253 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    12261 50 0 1 0 0 0 0 2 3 0.06 0.04 2.00 0.00
    12267 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12275 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12277 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    12292 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12295 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    12298 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.6 1.1 0.0 0.0 0.0 0.0 0.5 2.3 0.05 0.02 3.25 1.25
± SEM                         0.01 0.01 0.65 0.53
 
Test Chemical C.I. Disperse yellow 3 
900         
 12256 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    12268 50 3 2 1 0 0 0 1 7 0.14 0.10 12.00 8.00
    12274 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12286 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    12288 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12291 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    12293 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    12299 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         1.5 1.0 0.1 0.0 0.0 0.0 0.3 2.9 0.06 0.04 5.00 3.25
± SEM                         0.01 0.01 1.31 1.13
 
Test Chemical C.I. Disperse yellow 3 
1800         
 12257 50 1 1 0 0 0 0 2 4 0.08 0.06 4.00 2.00
    12262 50 1 0 0 0 0 0 2 3 0.06 0.06 2.00 2.00
    12264 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12266 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    12269 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    12279 50 1 2 0 0 0 0 1 4 0.08 0.04 4.00 2.00
    12289 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    12297 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 1.0 0.0 0.0 0.0 0.0 0.8 2.6 0.05 0.03 3.00 1.50
± SEM                         0.01 0.01 0.38 0.33
 
Vehicle Control No Stressor 
 0         
 12258 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12265 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12276 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12278 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12285 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12294 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12296 50 1 0 0 0 0 0 0 1 0.02 0.02 4.00 4.00
    12305 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.4 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.50 1.75
± SEM                         0.00 0.01 0.50 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation