| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01796-0012-0000-8 |
| Chemical Name: | C.I. Disperse yellow 3 |
| CASRN: | 2832-40-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 221078_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 04/18/1989 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11770 | 25 | 6.72 | ± | 0.368 |
| 11781 | 25 | 7.74 | ± | 0.970 | |||
| 11799 | 24 | 6.18 | ± | 0.494 | |||
| 11811 | 25 | 5.93 | ± | 0.782 | |||
| Average | 6.65 | ± | 0.403 | ||||
| Test Chemical | C.I. Disperse yellow 3 |
450 |
11769 | 25 | 6.08 | ± | 0.675 |
| 11772 | 25 | 7.09 | ± | 0.600 | |||
| 11776 | 24 | 4.55 | ± | 0.344 | |||
| 11783 | 25 | 6.24 | ± | 0.629 | |||
| Average | 6.01 | ± | 0.530 | ||||
| Test Chemical | C.I. Disperse yellow 3 |
900 |
11767 | 25 | 9.24 | ± | 0.985 |
| 11775 | 24 | 6.88 | ± | 0.905 | |||
| 11778 | 25 | 8.75 | ± | 1.322 | |||
| 11784 | 25 | 8.68 | ± | 0.898 | |||
| Average | 8.19 | ± | 0.518 | ||||
| Test Chemical | C.I. Disperse yellow 3 |
1800 |
11766 | 25 | 8.71 | ± | 0.542 |
| 11768 | 25 | 10.12 | ± | 0.813 | |||
| 11773 | 25 | 6.50 | ± | 0.526 | |||
| 11782 | 25 | 11.20 | ± | 0.988 | |||
| Average | 9.13 | ± | 1.015 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11765 | 25 | 14.72 | ± | 1.341 |
| 11777 | 25 | 17.41 | ± | 1.129 | |||
| 11803 | 25 | 15.87 | ± | 1.680 | |||
| 11806 | 25 | 18.80 | ± | 1.971 | |||
| Average | 16.69 | ± | 0.892 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed