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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0015-0000-8
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 223649_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/30/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 3777 50 6 8 0 0 0 0 1 15 0.30 0.14 20.00 10.00
    3778 50 5 5 0 0 0 0 1 11 0.22 0.12 14.00 8.00
    3784 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3785 50 5 4 0 0 0 0 1 10 0.20 0.12 10.00 8.00
    3787 50 7 7 0 0 0 1 0 15 0.30 0.16 24.00 14.00
    3789 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    3791 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3793 50 4 2 0 0 0 0 0 6 0.12 0.08 8.00 6.00
Average         4.3 3.4 0.0 0.0 0.0 0.1 0.4 8.1 0.16 0.10 11.25 7.50
± SEM                         0.04 0.02 2.64 1.18
 
Test Chemical 3-Chloro-2-methylpropene 
75         
 3747 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3750 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    3768 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3771 50 1 1 0 0 0 0 0 2 0.04 0.02 2.00 2.00
    3773 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    3786 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3788 50 2 1 1 0 0 0 0 4 0.08 0.06 6.00 4.00
    3796 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
Average         0.9 0.4 0.1 0.0 0.0 0.0 0.4 1.8 0.04 0.03 2.25 1.75
± SEM                         0.01 0.01 0.70 0.59
 
Test Chemical 3-Chloro-2-methylpropene 
150         
 3748 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3752 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3753 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3757 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    3759 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3760 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3765 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3769 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.1 0.1 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.02 2.25 2.00
± SEM                         0.01 0.00 0.45 0.38
 
Test Chemical 3-Chloro-2-methylpropene 
300         
 3749 50 2 1 0 0 0 0 0 3 0.06 0.04 8.00 6.00
    3751 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3754 50 3 1 0 0 0 0 1 5 0.10 0.08 6.00 6.00
    3761 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    3762 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    3763 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    3764 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    3770 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         1.8 1.0 0.0 0.0 0.0 0.0 0.4 3.1 0.06 0.04 5.25 3.75
± SEM                         0.01 0.01 1.00 0.88
 
Vehicle Control No Stressor 
 0         
 3772 50 1 2 0 0 0 0 2 5 0.10 0.06 8.00 4.00
    3774 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    3775 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3780 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    3781 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3783 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    3790 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3792 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.6 0.0 0.0 0.0 0.0 0.3 1.8 0.04 0.02 3.00 1.75
± SEM                         0.01 0.01 1.31 0.80
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation