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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0015-0000-8
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 223649_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/27/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 4540 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4554 50 3 1 0 0 0 0 0 4 0.08 0.06 4.00 4.00
    4562 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4575 50 5 1 0 0 0 0 5 11 0.22 0.20 16.00 16.00
    4577 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    4584 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4594 50 6 1 0 0 0 0 0 7 0.14 0.12 14.00 12.00
    4604 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         2.6 0.9 0.0 0.0 0.0 0.0 0.6 4.1 0.08 0.07 7.00 5.75
± SEM                         0.02 0.02 1.96 1.94
 
Test Chemical 3-Chloro-2-methylpropene 
225         
 4548 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4558 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    4570 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    4572 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4588 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4593 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4603 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4605 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.4 0.1 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.50 0.37
 
Test Chemical 3-Chloro-2-methylpropene 
300         
 4542 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4543 50 1 0 0 0 0 0 0 1 0.02 0.02 0.00 0.00
    4555 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4557 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4563 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4578 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4595 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    4598 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.02 0.02 1.25 1.25
± SEM                         0.00 0.00 0.53 0.53
 
Vehicle Control No Stressor 
 0         
 4547 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4565 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4574 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4580 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4582 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4587 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4591 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4601 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         1.1 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.03 0.02 3.00 2.25
± SEM                         0.01 0.00 0.53 0.45
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation