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Study Information
Study Attribute Value
CEBS Accession Number: 002-01432-0015-0000-8
Chemical Name: 3-Chloro-2-methylpropene
CASRN: 563-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 223649_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/11/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 6645 50 42 17 0 0 0 2 0 61 1.22 0.88 42.00 32.00
    6649 50 27 9 1 0 0 1 1 39 0.78 0.60 28.00 20.00
    6652 50 41 19 0 3 0 3 0 66 1.32 0.88 36.00 24.00
    6692 50 36 3 0 0 0 0 0 39 0.78 0.72 22.00 18.00
    6697 50 14 4 0 0 0 0 1 19 0.38 0.30 24.00 24.00
    6702 50 9 5 1 11 0 0 0 26 0.52 0.20 24.00 16.00
    6712 50 29 5 1 0 0 0 1 36 0.72 0.62 26.00 24.00
    6716 50 49 9 0 0 0 0 0 58 1.16 0.98 40.00 34.00
Average         30.9 8.9 0.4 1.8 0.0 0.8 0.4 43.0 0.86 0.65 30.25 24.00
± SEM                         0.12 0.10 2.79 2.24
 
Test Chemical 3-Chloro-2-methylpropene 
150         
 6682 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6686 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6690 50 4 6 0 0 0 0 0 10 0.20 0.08 10.00 8.00
    6693 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6698 50 5 2 0 0 0 0 0 7 0.14 0.10 8.00 6.00
    6706 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6707 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6711 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.3 1.4 0.0 0.0 0.0 0.0 0.0 2.6 0.05 0.03 3.25 2.00
± SEM                         0.03 0.01 1.31 1.13
 
Test Chemical 3-Chloro-2-methylpropene 
300         
 6685 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    6691 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6696 50 0 4 0 0 0 0 1 5 0.10 0.02 10.00 2.00
    6699 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6703 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6709 50 4 5 0 0 0 0 0 9 0.18 0.08 12.00 8.00
    6713 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6717 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.8 0.0 0.0 0.0 0.0 0.1 2.8 0.06 0.02 4.50 2.00
± SEM                         0.02 0.01 1.72 1.00
 
Test Chemical 3-Chloro-2-methylpropene 
600         
 6684 50 3 2 0 2 0 0 0 7 0.14 0.06 14.00 8.00
    6689 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6695 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6701 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    6704 50 5 9 0 0 0 0 0 14 0.28 0.10 20.00 8.00
    6714 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    6715 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6718 50 2 3 0 0 0 0 0 5 0.10 0.04 10.00 4.00
Average         2.3 2.0 0.0 0.3 0.0 0.0 0.0 4.5 0.09 0.05 8.00 4.50
± SEM                         0.03 0.01 2.24 0.82
 
Vehicle Control No Stressor 
 0         
 6667 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6676 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6683 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    6688 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6694 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    6700 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    6705 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    6719 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.6 0.01 0.01 1.25 0.50
± SEM                         0.01 0.00 0.53 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation