| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01432-0014-0000-7 |
| Chemical Name: | 3-Chloro-2-methylpropene |
| CASRN: | 563-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 223649_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/15/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3682 | 25 | 5.83 | ± | 0.603 |
| 3684 | 25 | 5.58 | ± | 0.592 | |||
| 3692 | 23 | 4.73 | ± | 0.479 | |||
| 3694 | 25 | 4.75 | ± | 0.781 | |||
| Average | 5.25 | ± | 0.283 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
75 |
3681 | 25 | 4.55 | ± | 0.613 |
| 3700 | 24 | 4.06 | ± | 0.344 | |||
| 3701 | 24 | 3.91 | ± | 0.459 | |||
| 3705 | 23 | 4.94 | ± | 0.545 | |||
| Average | 4.36 | ± | 0.236 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
150 |
3678 | 24 | 6.79 | ± | 0.708 |
| 3683 | 25 | 4.48 | ± | 0.544 | |||
| 3685 | 25 | 6.46 | ± | 0.667 | |||
| 3696 | 25 | 7.08 | ± | 0.532 | |||
| Average | 6.20 | ± | 0.589 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
300 |
3688 | 25 | 8.15 | ± | 1.127 |
| 3689 | 25 | 8.51 | ± | 0.774 | |||
| 3698 | 25 | 5.75 | ± | 0.656 | |||
| 3704 | 25 | 8.60 | ± | 0.985 | |||
| Average | 7.74 | ± | 0.676 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3686 | 25 | 12.42 | ± | 1.194 |
| 3693 | 25 | 9.05 | ± | 0.841 | |||
| 3699 | 25 | 7.67 | ± | 0.765 | |||
| 3702 | 25 | 9.84 | ± | 0.855 | |||
| Average | 9.75 | ± | 0.998 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed