| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01432-0014-0000-7 |
| Chemical Name: | 3-Chloro-2-methylpropene |
| CASRN: | 563-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 223649_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/23/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
5716 | 25 | 6.23 | ± | 0.423 |
| 5722 | 24 | 4.99 | ± | 0.459 | |||
| 5739 | 25 | 4.17 | ± | 0.403 | |||
| 5740 | 25 | 5.01 | ± | 0.328 | |||
| Average | 5.10 | ± | 0.425 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
75 |
5705 | 25 | 4.67 | ± | 0.463 |
| 5711 | 25 | 5.18 | ± | 0.486 | |||
| 5717 | 24 | 5.14 | ± | 0.472 | |||
| 5720 | 25 | 4.69 | ± | 0.429 | |||
| Average | 4.92 | ± | 0.138 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
150 |
5702 | 25 | 5.75 | ± | 0.434 |
| 5707 | 24 | 4.78 | ± | 0.531 | |||
| 5710 | 25 | 6.49 | ± | 0.483 | |||
| 5735 | 25 | 5.39 | ± | 0.457 | |||
| Average | 5.62 | ± | 0.358 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
300 |
5708 | 25 | 3.41 | ± | 0.341 |
| 5724 | 25 | 4.79 | ± | 0.383 | |||
| 5729 | 25 | 5.43 | ± | 0.577 | |||
| Average | 4.55 | ± | 0.597 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5703 | 25 | 11.15 | ± | 1.283 |
| 5713 | 25 | 13.12 | ± | 1.040 | |||
| 5719 | 25 | 13.22 | ± | 0.808 | |||
| 5721 | 25 | 13.44 | ± | 0.918 | |||
| Average | 12.73 | ± | 0.531 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed