| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01432-0014-0000-7 |
| Chemical Name: | 3-Chloro-2-methylpropene |
| CASRN: | 563-47-3 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 223649_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/28/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6557 | 25 | 4.63 | ± | 0.498 |
| 6572 | 25 | 5.67 | ± | 0.407 | |||
| 6577 | 25 | 4.77 | ± | 0.371 | |||
| 6578 | 25 | 5.51 | ± | 0.424 | |||
| Average | 5.15 | ± | 0.261 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
225 |
6543 | 25 | 5.31 | ± | 0.519 |
| 6547 | 25 | 5.93 | ± | 0.618 | |||
| 6548 | 25 | 4.79 | ± | 0.446 | |||
| 6553 | 25 | 4.27 | ± | 0.422 | |||
| Average | 5.07 | ± | 0.355 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
300 |
6540 | 25 | 7.81 | ± | 0.706 |
| 6550 | 25 | 7.28 | ± | 0.934 | |||
| 6552 | 25 | 6.43 | ± | 0.472 | |||
| 6554 | 25 | 7.47 | ± | 0.829 | |||
| Average | 7.25 | ± | 0.295 | ||||
| Test Chemical | 3-Chloro-2-methylpropene |
375 |
6539 | 25 | 13.02 | ± | 0.984 |
| 6541 | 25 | 7.96 | ± | 0.727 | |||
| 6549 | 25 | 10.42 | ± | 0.811 | |||
| Average | 10.45 | ± | 1.460 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6551 | 25 | 8.20 | ± | 0.751 |
| 6571 | 25 | 7.85 | ± | 0.651 | |||
| 6582 | 25 | 9.00 | ± | 0.564 | |||
| 6584 | 25 | 10.22 | ± | 0.823 | |||
| Average | 8.82 | ± | 0.525 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed