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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0012-0000-4
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 227174_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
04/21/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 3443 50 8 7 0 0 0 0 0 15 0.30 0.16 24.00 16.00
    3446 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 8.00
    3452 50 4 2 0 0 0 0 0 6 0.12 0.08 12.00 4.00
    3455 50 6 8 0 0 0 0 0 14 0.28 0.12 28.00 12.00
    3478 50 5 8 0 0 0 0 0 13 0.26 0.10 18.00 8.00
    3481 50 5 6 0 0 0 0 1 12 0.24 0.12 18.00 12.00
    3487 50 6 12 0 0 0 0 0 18 0.36 0.12 24.00 10.00
    3493 50 5 11 0 0 0 0 0 16 0.32 0.10 18.00 8.00
Average         5.5 7.1 0.0 0.0 0.0 0.0 0.1 12.8 0.26 0.11 19.50 9.75
± SEM                         0.03 0.01 1.92 1.28
 
Test Chemical 4,4'-Oxydianiline 
125         
 3445 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    3448 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3451 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3453 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3463 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3470 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3472 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    3476 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.3 0.0 0.0 0.0 0.0 0.1 0.8 0.02 0.01 1.25 0.75
± SEM                         0.01 0.00 0.65 0.37
 
Test Chemical 4,4'-Oxydianiline 
250         
 3442 50 0 0 0 0 0 0 1 1 0.02 0.02 2.00 2.00
    3447 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3454 50 0 1 1 0 0 0 0 2 0.04 0.02 2.00 2.00
    3462 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3467 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3483 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    3484 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.6 0.1 0.0 0.0 0.0 0.1 1.3 0.03 0.01 2.00 1.25
± SEM                         0.01 0.00 0.38 0.37
 
Test Chemical 4,4'-Oxydianiline 
500         
 3450 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3464 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3465 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3468 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3469 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    3471 50 0 1 0 0 0 0 1 2 0.04 0.02 4.00 2.00
    3474 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    3475 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.9 0.0 0.0 0.0 0.0 0.1 1.5 0.03 0.01 3.00 1.25
± SEM                         0.01 0.01 0.65 0.65
 
Vehicle Control No Stressor 
 0         
 3444 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    3456 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3458 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    3473 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    3479 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3488 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    3490 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    3492 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         0.5 0.8 0.0 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.25 1.00
± SEM                         0.01 0.01 0.70 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation