| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01468-0012-0000-4 |
| Chemical Name: | 4,4'-Oxydianiline |
| CASRN: | 101-80-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 227174_CA |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
|---|---|---|---|---|---|---|---|
| 11/04/1986 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 36 hour | Positive |
| Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
| (+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
| Positive Control | Dimethylbenzanthracene |
100 |
4035 | 50 | 9 | 3 | 0 | 0 | 0 | 0 | 0 | 12 | 0.24 | 0.18 | 16.00 | 14.00 |
| 4042 | 50 | 5 | 3 | 1 | 0 | 0 | 1 | 0 | 10 | 0.20 | 0.14 | 16.00 | 14.00 | |||
| 4046 | 50 | 37 | 1 | 0 | 0 | 0 | 0 | 0 | 38 | 0.76 | 0.74 | 20.00 | 18.00 | |||
| 4055 | 50 | 10 | 2 | 0 | 0 | 0 | 1 | 1 | 14 | 0.28 | 0.24 | 18.00 | 16.00 | |||
| 4056 | 50 | 13 | 8 | 0 | 0 | 0 | 1 | 1 | 23 | 0.46 | 0.30 | 28.00 | 18.00 | |||
| 4058 | 50 | 31 | 6 | 0 | 0 | 0 | 0 | 0 | 37 | 0.74 | 0.62 | 32.00 | 30.00 | |||
| Average | 17.5 | 3.8 | 0.2 | 0.0 | 0.0 | 0.5 | 0.3 | 22.3 | 0.45 | 0.37 | 21.67 | 18.33 | ||||
| ± SEM | 0.10 | 0.10 | 2.75 | 2.44 | ||||||||||||
| Test Chemical | 4,4'-Oxydianiline |
375 |
4036 | 50 | 10 | 6 | 0 | 1 | 0 | 0 | 1 | 18 | 0.36 | 0.22 | 28.00 | 22.00 |
| 4038 | 50 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.12 | 12.00 | 12.00 | |||
| 4041 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 4044 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 4048 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
| 4053 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 8.00 | 6.00 | |||
| Average | 4.0 | 1.2 | 0.0 | 0.2 | 0.0 | 0.0 | 0.3 | 5.7 | 0.11 | 0.09 | 9.33 | 8.00 | ||||
| ± SEM | 0.05 | 0.03 | 4.06 | 3.18 | ||||||||||||
| Test Chemical | 4,4'-Oxydianiline |
500 |
4032 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 |
| 4040 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
| Average | 2.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04 | 0.04 | 4.00 | 4.00 | ||||
| ± SEM | 0.00 | 0.00 | 0.00 | 0.00 | ||||||||||||
| Vehicle Control | No Stressor |
0 |
4039 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 |
| 4043 | 50 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.06 | 8.00 | 6.00 | |||
| 4047 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
| 4049 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| 4050 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
| 4054 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 2 | 4 | 0.08 | 0.06 | 4.00 | 2.00 | |||
| 4057 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0.04 | 0.04 | 2.00 | 2.00 | |||
| 4060 | 50 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
| Average | 1.1 | 0.5 | 0.0 | 0.0 | 0.0 | 0.1 | 0.4 | 2.1 | 0.04 | 0.03 | 3.50 | 2.50 | ||||
| ± SEM | 0.01 | 0.01 | 0.91 | 0.63 | ||||||||||||
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation