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Study Information
Study Attribute Value
CEBS Accession Number: 002-01468-0012-0000-4
Chemical Name: 4,4'-Oxydianiline
CASRN: 101-80-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 227174_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/23/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5556 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5574 50 7 2 0 0 0 0 0 9 0.18 0.14 16.00 14.00
    5579 50 9 5 0 0 0 0 0 14 0.28 0.18 16.00 14.00
    5594 50 6 0 2 0 0 0 0 8 0.16 0.16 14.00 14.00
    5596 50 22 8 1 0 0 0 0 31 0.62 0.46 24.00 24.00
    5606 50 22 4 1 0 0 0 0 27 0.54 0.46 22.00 20.00
    5609 50 43 4 0 0 0 0 0 47 0.94 0.86 24.00 22.00
    5612 50 7 4 0 0 0 0 0 11 0.22 0.14 14.00 10.00
Average         14.8 3.5 0.5 0.0 0.0 0.0 0.0 18.8 0.38 0.31 17.00 15.25
± SEM                         0.11 0.10 2.17 2.33
 
Test Chemical 4,4'-Oxydianiline 
87.5       
 5557 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5565 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5566 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5570 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    5580 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5584 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5588 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5595 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 1.75 1.25
± SEM                         0.01 0.01 0.45 0.53
 
Test Chemical 4,4'-Oxydianiline 
175         
 5562 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5568 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    5573 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5575 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5581 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5589 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5598 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5605 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.8 0.5 0.0 0.0 0.0 0.0 0.1 1.4 0.03 0.02 2.50 1.50
± SEM                         0.01 0.00 0.63 0.50
 
Test Chemical 4,4'-Oxydianiline 
350         
 5555 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    5576 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5577 50 1 1 2 1 0 0 0 5 0.10 0.06 6.00 6.00
    5583 50 2 1 0 2 0 0 0 5 0.10 0.04 8.00 2.00
    5587 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5593 50 0 1 0 4 0 0 0 5 0.10 0.00 6.00 0.00
    5599 50 3 0 3 1 0 0 0 7 0.14 0.12 12.00 10.00
    5602 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.1 0.6 0.8 1.0 0.0 0.0 0.0 3.5 0.07 0.04 5.50 3.25
± SEM                         0.02 0.01 1.30 1.31
 
Vehicle Control No Stressor 
 0         
 5558 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5560 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5578 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5582 50 0 3 0 0 0 0 1 4 0.08 0.02 4.00 0.00
    5592 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    5597 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    5603 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5610 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.5 0.0 0.0 0.0 0.0 0.3 1.6 0.03 0.02 2.00 1.25
± SEM                         0.01 0.01 0.76 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation