| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01468-0011-0000-3 |
| Chemical Name: | 4,4'-Oxydianiline |
| CASRN: | 101-80-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 227174_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 04/28/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
3494 | 24 | 4.73 | ± | 0.488 |
| 3498 | 25 | 4.33 | ± | 0.385 | |||
| 3514 | 24 | 4.38 | ± | 0.380 | |||
| 3516 | 24 | 5.63 | ± | 0.679 | |||
| Average | 4.77 | ± | 0.301 | ||||
| Test Chemical | 4,4'-Oxydianiline |
75 |
3499 | 25 | 6.87 | ± | 0.586 |
| 3507 | 26 | 5.78 | ± | 0.515 | |||
| 3511 | 25 | 4.92 | ± | 0.506 | |||
| 3517 | 25 | 6.89 | ± | 0.646 | |||
| Average | 6.11 | ± | 0.476 | ||||
| Test Chemical | 4,4'-Oxydianiline |
150 |
3495 | 25 | 6.97 | ± | 0.606 |
| 3509 | 25 | 5.74 | ± | 0.588 | |||
| 3510 | 25 | 7.08 | ± | 0.673 | |||
| 3512 | 24 | 5.11 | ± | 0.538 | |||
| Average | 6.24 | ± | 0.479 | ||||
| Test Chemical | 4,4'-Oxydianiline |
300 |
3502 | 25 | 5.55 | ± | 0.604 |
| 3505 | 25 | 6.22 | ± | 0.601 | |||
| 3508 | 25 | 3.71 | ± | 0.408 | |||
| 3513 | 25 | 6.07 | ± | 0.577 | |||
| Average | 5.38 | ± | 0.578 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
3497 | 25 | 10.98 | ± | 0.742 |
| 3500 | 25 | 13.58 | ± | 0.830 | |||
| 3506 | 25 | 10.68 | ± | 0.724 | |||
| 3515 | 25 | 12.91 | ± | 0.830 | |||
| Average | 12.05 | ± | 0.714 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed