| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01468-0011-0000-3 |
| Chemical Name: | 4,4'-Oxydianiline |
| CASRN: | 101-80-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 227174_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/13/1987 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
5353 | 25 | 4.92 | ± | 0.476 |
| 5357 | 25 | 4.92 | ± | 0.447 | |||
| 5363 | 25 | 5.70 | ± | 0.654 | |||
| 5366 | 24 | 5.11 | ± | 0.474 | |||
| Average | 5.16 | ± | 0.186 | ||||
| Test Chemical | 4,4'-Oxydianiline |
75 |
5350 | 25 | 6.86 | ± | 0.497 |
| 5360 | 25 | 5.63 | ± | 0.473 | |||
| 5365 | 25 | 4.95 | ± | 0.354 | |||
| 5372 | 25 | 5.76 | ± | 0.496 | |||
| Average | 5.80 | ± | 0.396 | ||||
| Test Chemical | 4,4'-Oxydianiline |
150 |
5351 | 25 | 6.13 | ± | 0.451 |
| 5354 | 25 | 5.79 | ± | 0.624 | |||
| 5358 | 25 | 4.46 | ± | 0.423 | |||
| 5368 | 25 | 8.18 | ± | 0.679 | |||
| Average | 6.14 | ± | 0.771 | ||||
| Test Chemical | 4,4'-Oxydianiline |
300 |
5352 | 25 | 4.27 | ± | 0.452 |
| 5355 | 25 | 6.80 | ± | 0.572 | |||
| 5371 | 25 | 5.94 | ± | 0.428 | |||
| Average | 5.67 | ± | 0.741 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
5349 | 25 | 11.22 | ± | 1.187 |
| 5359 | 25 | 13.83 | ± | 1.092 | |||
| 5362 | 25 | 12.23 | ± | 1.248 | |||
| 5369 | 25 | 14.07 | ± | 1.068 | |||
| Average | 12.83 | ± | 0.677 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed