| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01468-0011-0000-3 |
| Chemical Name: | 4,4'-Oxydianiline |
| CASRN: | 101-80-4 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 227174_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 10/28/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
6557 | 25 | 4.63 | ± | 0.498 |
| 6572 | 25 | 5.67 | ± | 0.407 | |||
| 6577 | 25 | 4.77 | ± | 0.371 | |||
| 6578 | 25 | 5.51 | ± | 0.424 | |||
| Average | 5.15 | ± | 0.261 | ||||
| Test Chemical | 4,4'-Oxydianiline |
150 |
6586 | 25 | 6.54 | ± | 0.827 |
| 6587 | 25 | 5.24 | ± | 0.622 | |||
| 6588 | 25 | 4.40 | ± | 0.464 | |||
| 6589 | 25 | 4.95 | ± | 0.528 | |||
| Average | 5.29 | ± | 0.454 | ||||
| Test Chemical | 4,4'-Oxydianiline |
225 |
6574 | 25 | 5.39 | ± | 0.510 |
| 6576 | 25 | 5.19 | ± | 0.526 | |||
| 6579 | 25 | 5.57 | ± | 0.569 | |||
| 6592 | 25 | 5.75 | ± | 0.546 | |||
| Average | 5.47 | ± | 0.121 | ||||
| Test Chemical | 4,4'-Oxydianiline |
300 |
6573 | 25 | 5.64 | ± | 0.511 |
| 6575 | 25 | 3.87 | ± | 0.410 | |||
| 6580 | 24 | 5.49 | ± | 0.543 | |||
| 6591 | 25 | 4.72 | ± | 0.470 | |||
| Average | 4.93 | ± | 0.408 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
6551 | 25 | 8.20 | ± | 0.751 |
| 6571 | 25 | 7.85 | ± | 0.651 | |||
| 6582 | 25 | 9.00 | ± | 0.564 | |||
| 6584 | 25 | 10.22 | ± | 0.823 | |||
| Average | 8.82 | ± | 0.525 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed