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Study Information
Study Attribute Value
CEBS Accession Number: 002-01265-0007-0000-3
Chemical Name: 2-Acetylaminofluorene
CASRN: 53-96-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 242744_CA
Study Result: Positive (Nonstandard Protocol)


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/20/1983 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive (Nonstandard Protocol)

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Test Chemical 2-Acetylaminofluorene 
125         
 1111 100 3 0 0 0 0 0 0 3 0.03 0.03 3.00 3.00
    1113 100 4 0 0 0 0 0 0 4 0.04 0.04 4.00 4.00
    1114 100 7 0 0 0 0 0 0 7 0.07 0.07 4.00 4.00
    1115 100 3 0 0 0 0 0 0 3 0.03 0.03 3.00 3.00
Average         4.3 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.04 0.04 3.50 3.50
± SEM                         0.01 0.01 0.29 0.29
 
Test Chemical 2-Acetylaminofluorene 
250         
 1116 100 1 0 0 0 0 0 0 1 0.01 0.01 1.00 1.00
    1118 100 3 0 0 0 0 0 0 3 0.03 0.03 3.00 3.00
    1119 100 2 0 0 0 0 0 0 2 0.02 0.02 2.00 2.00
    1148 100 5 0 0 0 0 0 0 5 0.05 0.05 5.00 5.00
Average         2.8 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.03 0.03 2.75 2.75
± SEM                         0.01 0.01 0.85 0.85
 
Test Chemical 2-Acetylaminofluorene 
500         
 1121 100 4 0 0 0 0 0 0 4 0.04 0.04 4.00 4.00
    1122 100 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1123 100 1 0 1 0 0 0 0 2 0.02 0.02 2.00 2.00
    1125 100 5 1 0 0 0 0 0 6 0.06 0.05 6.00 5.00
Average         2.5 0.3 0.3 0.0 0.0 0.0 0.0 3.0 0.03 0.03 3.00 2.75
± SEM                         0.01 0.01 1.29 1.11
 
Vehicle Control No Stressor 
 0         
 1131 100 4 3 0 0 0 0 0 7 0.07 0.04 6.00 3.00
    1132 100 11 0 0 0 0 0 2 13 0.13 0.13 7.00 7.00
    1134 100 4 1 0 0 0 0 0 5 0.05 0.04 4.00 4.00
    1135 100 8 0 0 0 0 0 0 8 0.08 0.08 6.00 6.00
Average         6.8 1.0 0.0 0.0 0.0 0.0 0.5 8.3 0.08 0.07 5.75 5.00
± SEM                         0.02 0.02 0.63 0.91
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation