| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01705-0014-0000-0 |
| Chemical Name: | Benzoin |
| CASRN: | 119-53-9 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 243271_SCE |
| Study Result: | Negative (Nonstandard Protocol) |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/14/1984 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
1366 | 25 | 3.80 | ± | 0.404 |
| 1367 | 25 | 5.96 | ± | 0.682 | |||
| 1368 | 25 | 4.13 | ± | 0.424 | |||
| 1369 | 25 | 4.54 | ± | 0.487 | |||
| Average | 4.61 | ± | 0.475 | ||||
| Test Chemical | Benzoin |
750 |
1346 | 25 | 4.83 | ± | 0.629 |
| 1347 | 23 | 6.24 | ± | 0.467 | |||
| 1348 | 25 | 4.90 | ± | 0.598 | |||
| 1349 | 25 | 4.98 | ± | 0.584 | |||
| Average | 5.22 | ± | 0.336 | ||||
| Test Chemical | Benzoin |
1500 |
1350 | 25 | 7.09 | ± | 0.628 |
| 1351 | 25 | 5.14 | ± | 0.613 | |||
| 1352 | 25 | 5.12 | ± | 0.609 | |||
| 1353 | 25 | 5.57 | ± | 0.630 | |||
| Average | 5.73 | ± | 0.465 | ||||
| Test Chemical | Benzoin |
3000 |
1316 | 25 | 4.08 | ± | 0.282 |
| 1317 | 25 | 5.12 | ± | 0.483 | |||
| 1318 | 25 | 4.43 | ± | 0.574 | |||
| 1319 | 25 | 6.25 | ± | 0.997 | |||
| Average | 4.97 | ± | 0.478 | ||||
| Positive Control | Dimethylbenzanthracene |
5 |
1325 | 25 | 9.33 | ± | 0.752 |
| 1326 | 25 | 10.33 | ± | 0.928 | |||
| 1327 | 25 | 10.93 | ± | 0.971 | |||
| 1328 | 25 | 12.00 | ± | 1.333 | |||
| Average | 10.64 | ± | 0.557 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed