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Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0018-0000-9
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 244282_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
07/15/1985 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 2479 50 4 8 0 0 0 0 0 12 0.24 0.08 16.00 6.00
    2486 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    2489 50 5 3 0 0 0 0 0 8 0.16 0.10 14.00 10.00
    2500 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 2.00
    2506 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    2515 50 2 6 0 0 0 0 1 9 0.18 0.06 14.00 6.00
    2517 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2522 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         2.5 3.0 0.0 0.0 0.0 0.0 0.1 5.6 0.11 0.05 9.00 4.75
± SEM                         0.03 0.01 1.81 1.00
 
Test Chemical Tribromomethane 
200         
 2480 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2484 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2498 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2502 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2503 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2507 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2509 50 1 2 0 0 0 0 1 4 0.08 0.04 4.00 2.00
    2512 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
Average         0.1 0.8 0.0 0.0 0.0 0.0 0.3 1.1 0.02 0.01 1.50 0.25
± SEM                         0.01 0.01 0.50 0.25
 
Test Chemical Tribromomethane 
400         
 2481 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2488 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2499 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2505 50 2 0 0 0 0 0 0 2 0.04 0.04 6.00 6.00
    2514 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2519 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    2523 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2526 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.4 0.0 0.0 0.0 0.0 0.1 1.1 0.02 0.02 2.25 1.50
± SEM                         0.01 0.01 0.80 0.82
 
Test Chemical Tribromomethane 
800         
 2490 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2491 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2492 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2494 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2495 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    2496 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    2511 50 0 0 0 0 0 0 2 2 0.04 0.04 0.00 0.00
    2521 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.4 0.9 0.02 0.01 1.00 0.50
± SEM                         0.01 0.01 0.38 0.33
 
Vehicle Control No Stressor 
 0         
 2482 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2483 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    2485 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    2487 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    2501 50 2 0 0 0 0 0 1 3 0.06 0.06 6.00 6.00
    2510 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    2518 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    2528 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.3 0.1 0.0 0.0 0.0 0.0 0.1 1.5 0.03 0.03 2.75 2.75
± SEM                         0.01 0.01 0.92 0.92
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation