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Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0018-0000-9
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 244282_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/20/1987 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 5391 50 12 10 0 0 0 0 0 22 0.44 0.24 32.00 22.00
    5407 50 10 4 0 0 0 0 0 14 0.28 0.20 20.00 18.00
    5409 50 68 4 0 0 0 0 0 72 1.44 1.36 38.00 36.00
    5416 50 35 3 0 0 0 0 0 38 0.76 0.70 20.00 14.00
    5432 50 22 8 0 0 0 0 0 30 0.60 0.44 24.00 16.00
    5449 50 21 7 0 0 0 0 1 29 0.58 0.44 22.00 18.00
    5460 50 14 24 0 0 0 0 1 39 0.78 0.30 18.00 12.00
    5461 50 14 2 0 0 0 0 1 17 0.34 0.30 12.00 8.00
Average         24.5 7.8 0.0 0.0 0.0 0.0 0.4 32.6 0.65 0.50 23.25 18.00
± SEM                         0.13 0.14 2.90 2.98
 
Test Chemical Tribromomethane 
200         
 5426 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5438 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5440 50 0 0 0 0 0 0 2 2 0.04 0.04 0.00 0.00
    5441 50 2 0 0 0 0 0 1 3 0.06 0.06 4.00 4.00
    5442 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5444 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5458 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         1.1 0.0 0.0 0.0 0.0 0.0 0.6 1.7 0.03 0.03 2.29 2.29
± SEM                         0.01 0.01 0.81 0.81
 
Test Chemical Tribromomethane 
400         
 5425 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    5428 50 1 1 0 0 0 0 0 2 0.04 0.02 6.00 4.00
    5431 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5435 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5437 50 5 1 0 0 0 0 0 6 0.12 0.10 10.00 10.00
    5446 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5455 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    5456 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.5 0.5 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.03 4.00 3.25
± SEM                         0.01 0.01 1.25 1.25
 
Test Chemical Tribromomethane 
800         
 5423 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    5424 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5427 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5433 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    5439 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    5443 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5447 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    5454 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.0 0.4 0.0 0.0 0.0 0.0 0.1 1.5 0.03 0.02 2.75 2.00
± SEM                         0.01 0.01 1.06 0.93
 
Vehicle Control No Stressor 
 0         
 5398 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    5400 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    5406 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    5420 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    5430 50 0 0 1 0 0 0 0 1 0.02 0.02 2.00 2.00
    5434 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5452 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    5462 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.3 0.1 0.0 0.0 0.0 0.1 0.9 0.02 0.01 1.50 1.00
± SEM                         0.01 0.01 0.63 0.53
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation