COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02934-0018-0000-9
Chemical Name: Tribromomethane
CASRN: 75-25-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 244282_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/16/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 7981 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    7989 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    7996 50 6 5 0 0 1 0 1 13 0.26 0.16 16.00 12.00
    8008 50 5 4 0 0 0 0 0 9 0.18 0.10 16.00 10.00
    8026 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 4.00
    8029 50 7 6 0 0 0 1 0 14 0.28 0.16 26.00 16.00
    8030 50 5 5 0 0 0 0 0 10 0.20 0.10 14.00 8.00
    8037 50 6 4 1 0 0 0 0 11 0.22 0.14 18.00 12.00
Average         4.8 3.4 0.1 0.0 0.1 0.1 0.1 8.6 0.17 0.11 14.00 9.50
± SEM                         0.03 0.02 2.39 1.35
 
Test Chemical Tribromomethane 
200         
 8011 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8012 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8013 50 2 0 0 0 0 0 1 3 0.06 0.06 6.00 6.00
    8018 50 0 5 0 0 0 0 0 5 0.10 0.00 8.00 0.00
    8019 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8024 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8027 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    8043 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 1.0 0.0 0.0 0.0 0.0 0.3 1.6 0.03 0.01 2.75 1.00
± SEM                         0.01 0.01 1.06 0.76
 
Test Chemical Tribromomethane 
400         
 8014 50 0 1 0 0 0 0 0 1 0.02 0.00 4.00 2.00
    8015 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8023 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8025 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8031 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8033 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8036 50 0 0 0 0 0 1 0 1 0.02 0.02 2.00 2.00
    8041 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         0.4 0.5 0.0 0.0 0.0 0.1 0.0 1.0 0.02 0.01 2.25 1.25
± SEM                         0.00 0.01 0.45 0.53
 
Test Chemical Tribromomethane 
800         
 8006 50 0 1 0 1 0 0 0 2 0.04 0.00 4.00 0.00
    8007 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8016 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8022 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8028 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8035 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    8039 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8042 50 2 2 0 0 0 0 2 6 0.12 0.08 8.00 4.00
Average         0.6 1.0 0.0 0.1 0.0 0.0 0.3 2.0 0.04 0.02 3.50 1.25
± SEM                         0.01 0.01 0.91 0.53
 
Vehicle Control No Stressor 
 0         
 7961 50 0 3 0 0 0 0 1 4 0.08 0.02 4.00 0.00
    7966 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    7974 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    7979 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    7982 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    7986 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8002 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 2.00
    8009 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 1.1 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.02 3.25 1.50
± SEM                         0.01 0.01 1.00 0.73
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation