| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02934-0017-0000-8 |
| Chemical Name: | Tribromomethane |
| CASRN: | 75-25-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 244282_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 07/11/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2466 | 23 | 2.40 | ± | 0.271 |
| 2471 | 24 | 3.29 | ± | 0.352 | |||
| 2475 | 24 | 3.09 | ± | 0.313 | |||
| 2476 | 23 | 3.53 | ± | 0.415 | |||
| Average | 3.08 | ± | 0.241 | ||||
| Test Chemical | Tribromomethane |
200 |
2463 | 24 | 3.72 | ± | 0.457 |
| 2464 | 25 | 3.33 | ± | 0.510 | |||
| 2468 | 22 | 2.53 | ± | 0.306 | |||
| 2470 | 23 | 2.53 | ± | 0.239 | |||
| Average | 3.05 | ± | 0.298 | ||||
| Test Chemical | Tribromomethane |
400 |
2457 | 25 | 4.91 | ± | 0.481 |
| 2458 | 25 | 4.17 | ± | 0.523 | |||
| 2460 | 23 | 2.98 | ± | 0.328 | |||
| 2473 | 21 | 3.21 | ± | 0.450 | |||
| Average | 3.85 | ± | 0.446 | ||||
| Test Chemical | Tribromomethane |
800 |
2459 | 25 | 3.61 | ± | 0.412 |
| 2461 | 25 | 4.86 | ± | 0.588 | |||
| 2467 | 25 | 2.46 | ± | 0.213 | |||
| 2474 | 24 | 4.08 | ± | 0.548 | |||
| Average | 3.74 | ± | 0.503 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2455 | 25 | 8.46 | ± | 0.779 |
| 2462 | 25 | 9.86 | ± | 0.936 | |||
| 2469 | 25 | 10.08 | ± | 1.033 | |||
| 2478 | 25 | 6.95 | ± | 0.664 | |||
| Average | 8.84 | ± | 0.725 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed