| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02934-0017-0000-8 |
| Chemical Name: | Tribromomethane |
| CASRN: | 75-25-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 244282_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/05/1987 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | IP/IJ x 1, 36 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
4629 | 25 | 4.24 | ± | 0.452 |
| 4640 | 25 | 4.38 | ± | 0.400 | |||
| 4674 | 25 | 5.08 | ± | 0.412 | |||
| 4679 | 25 | 3.94 | ± | 0.372 | |||
| Average | 4.41 | ± | 0.242 | ||||
| Test Chemical | Tribromomethane |
200 |
4624 | 24 | 5.14 | ± | 0.586 |
| 4666 | 25 | 6.16 | ± | 0.615 | |||
| 4670 | 25 | 3.88 | ± | 0.333 | |||
| 4677 | 25 | 4.73 | ± | 0.468 | |||
| Average | 4.98 | ± | 0.473 | ||||
| Test Chemical | Tribromomethane |
400 |
4626 | 25 | 5.73 | ± | 0.667 |
| 4634 | 25 | 6.27 | ± | 0.612 | |||
| 4636 | 25 | 11.20 | ± | 0.929 | |||
| 4662 | 25 | 4.72 | ± | 0.540 | |||
| Average | 6.99 | ± | 1.443 | ||||
| Test Chemical | Tribromomethane |
800 |
4613 | 25 | 9.55 | ± | 0.756 |
| 4620 | 25 | 10.22 | ± | 0.913 | |||
| 4642 | 25 | 6.93 | ± | 0.484 | |||
| 4672 | 25 | 6.40 | ± | 0.493 | |||
| Average | 8.27 | ± | 0.945 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
4625 | 25 | 10.74 | ± | 0.953 |
| 4658 | 25 | 11.91 | ± | 0.943 | |||
| 4676 | 25 | 12.57 | ± | 1.067 | |||
| Average | 11.74 | ± | 0.535 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed