| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01525-0013-0000-9 |
| Chemical Name: | 5,5-Diphenylhydantoin (phenytoin) |
| CASRN: | 57-41-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 252423_SCE |
| Study Result: | Equivocal |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/04/1985 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
2535 | 24 | 5.90 | ± | 0.644 |
| 2539 | 25 | 5.89 | ± | 0.758 | |||
| 2542 | 25 | 4.50 | ± | 0.536 | |||
| 2546 | 25 | 5.32 | ± | 0.614 | |||
| Average | 5.39 | ± | 0.330 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
62.5 |
2541 | 25 | 3.82 | ± | 0.446 |
| 2550 | 24 | 4.27 | ± | 0.568 | |||
| 2553 | 25 | 5.65 | ± | 0.673 | |||
| 2556 | 24 | 4.36 | ± | 0.524 | |||
| Average | 4.53 | ± | 0.393 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
125 |
2530 | 25 | 7.91 | ± | 0.900 |
| 2536 | 25 | 7.74 | ± | 0.921 | |||
| 2538 | 25 | 8.34 | ± | 1.020 | |||
| 2558 | 24 | 7.48 | ± | 0.792 | |||
| Average | 7.88 | ± | 0.182 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
250 |
2549 | 25 | 4.24 | ± | 0.383 |
| 2551 | 25 | 5.46 | ± | 0.664 | |||
| 2554 | 25 | 8.07 | ± | 1.058 | |||
| 2555 | 24 | 3.02 | ± | 0.374 | |||
| Average | 5.23 | ± | 1.080 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
2532 | 25 | 10.85 | ± | 1.277 |
| 2533 | 25 | 11.07 | ± | 1.065 | |||
| 2543 | 25 | 10.68 | ± | 1.133 | |||
| 2557 | 25 | 5.69 | ± | 0.668 | |||
| Average | 9.58 | ± | 1.296 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed