| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01525-0013-0000-9 |
| Chemical Name: | 5,5-Diphenylhydantoin (phenytoin) |
| CASRN: | 57-41-0 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 252423_SCE |
| Study Result: | Equivocal |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/02/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Equivocal |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
7802 | 25 | 4.78 | ± | 0.434 |
| 7812 | 25 | 4.29 | ± | 0.419 | |||
| 7822 | 25 | 3.88 | ± | 0.422 | |||
| 7848 | 25 | 8.59 | ± | 0.788 | |||
| Average | 5.40 | ± | 1.084 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
25 |
7791 | 25 | 6.79 | ± | 0.794 |
| 7795 | 25 | 5.42 | ± | 0.461 | |||
| 7800 | 25 | 7.71 | ± | 0.726 | |||
| 7801 | 25 | 4.67 | ± | 0.397 | |||
| Average | 6.16 | ± | 0.682 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
50 |
7790 | 25 | 7.01 | ± | 0.692 |
| 7805 | 25 | 6.87 | ± | 0.636 | |||
| 7807 | 25 | 8.42 | ± | 1.008 | |||
| 7808 | 25 | 5.38 | ± | 0.427 | |||
| Average | 6.93 | ± | 0.623 | ||||
| Test Chemical | 5,5-Diphenylhydantoin (phenytoin) |
100 |
7792 | 25 | 6.01 | ± | 0.413 |
| 7794 | 25 | 4.98 | ± | 0.598 | |||
| 7796 | 25 | 9.00 | ± | 1.106 | |||
| 7806 | 25 | 10.14 | ± | 1.025 | |||
| Average | 7.56 | ± | 1.217 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
7797 | 25 | 13.47 | ± | 0.669 |
| 7811 | 25 | 15.09 | ± | 0.784 | |||
| 7829 | 25 | 11.80 | ± | 0.971 | |||
| 7834 | 25 | 14.43 | ± | 0.964 | |||
| Average | 13.69 | ± | 0.715 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed