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Study Information
Study Attribute Value
CEBS Accession Number: 002-02137-0017-0000-3
Chemical Name: Ethyl acrylate
CASRN: 140-88-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 272157_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
11/14/1988 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 9088 50 9 9 0 0 0 0 0 18 0.36 0.18 22.00 14.00
    9089 50 7 6 0 0 0 0 0 13 0.26 0.14 24.00 14.00
    9090 50 14 16 2 0 0 0 0 32 0.64 0.32 42.00 28.00
    9091 50 20 24 0 0 0 0 0 44 0.88 0.40 44.00 26.00
    9093 50 5 9 0 0 0 0 0 14 0.28 0.10 22.00 8.00
    9094 50 3 4 0 0 0 0 0 7 0.14 0.06 6.00 4.00
    9095 50 1 3 1 0 0 0 0 5 0.10 0.04 10.00 4.00
    9096 50 5 4 0 0 0 0 0 9 0.18 0.10 12.00 6.00
Average         8.0 9.4 0.4 0.0 0.0 0.0 0.0 17.8 0.36 0.17 22.75 13.00
± SEM                         0.10 0.05 4.97 3.36
 
Test Chemical Ethyl acrylate 
275         
 9018 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    9019 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9020 50 4 0 0 0 0 0 0 4 0.08 0.08 4.00 4.00
    9021 50 3 1 0 0 0 0 0 4 0.08 0.06 4.00 4.00
    9022 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    9023 50 4 1 1 0 0 0 0 6 0.12 0.10 10.00 10.00
    9024 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9025 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
Average         1.9 0.8 0.3 0.0 0.0 0.0 0.0 2.9 0.06 0.04 4.25 3.25
± SEM                         0.01 0.01 1.16 1.25
 
Test Chemical Ethyl acrylate 
550         
 9028 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9029 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    9030 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9031 50 4 0 0 0 0 0 0 4 0.08 0.08 4.00 4.00
    9032 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9033 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    9034 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    9035 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
Average         1.5 1.3 0.0 0.0 0.0 0.0 0.0 2.8 0.06 0.03 4.50 2.50
± SEM                         0.01 0.01 0.98 0.50
 
Test Chemical Ethyl acrylate 
1100         
 9038 50 2 5 0 0 0 0 0 7 0.14 0.04 6.00 4.00
    9039 50 2 5 0 0 0 0 0 7 0.14 0.04 10.00 4.00
    9040 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    9041 50 0 6 0 0 0 0 0 6 0.12 0.00 10.00 0.00
    9042 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    9043 50 4 6 0 0 0 0 1 11 0.22 0.10 16.00 8.00
    9044 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    9045 50 2 4 2 0 0 0 0 8 0.16 0.08 16.00 8.00
Average         2.0 4.0 0.3 0.0 0.0 0.0 0.1 6.4 0.13 0.05 10.00 4.50
± SEM                         0.02 0.01 1.41 0.98
 
Vehicle Control No Stressor 
 0         
 9078 50 7 1 0 0 0 0 0 8 0.16 0.14 10.00 8.00
    9079 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    9080 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9081 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    9082 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    9083 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    9084 50 3 5 1 0 0 0 0 9 0.18 0.08 10.00 6.00
    9085 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
Average         2.1 1.1 0.1 0.0 0.0 0.0 0.0 3.4 0.07 0.05 4.75 3.25
± SEM                         0.02 0.02 1.31 1.06
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation