Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02137-0017-0000-3 |
Chemical Name: | Ethyl acrylate |
CASRN: | 140-88-5 |
NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
NTP Study ID: | 272157_CA |
Study Result: | Negative |
Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.
Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Result |
---|---|---|---|---|---|---|---|
02/05/1990 | Bone Marrow | 36 | Male | Mouse | B6C3F1 | Intraperitoneal Injection x 1/study, 36 hour | Negative |
Dose (mg/kg) |
Animal Number |
No. Cells |
Chromatid | Isochromatid | Exchanges | Aberrations | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Breaks | Gaps | Breaks | Gaps | 'Tid | 'Some | Other | Total | Per Cell | % Cells w/ Abs | |||||||
(+ Gaps) | (- Gaps) | (+ Gaps) | (- Gaps) | |||||||||||||
Positive Control | Dimethylbenzanthracene |
50 |
10850 | 50 | 71 | 1 | 0 | 0 | 1 | 0 | 0 | 73 | 1.46 | 1.44 | 30.00 | 30.00 |
10851 | 50 | 6 | 4 | 3 | 1 | 0 | 0 | 0 | 14 | 0.28 | 0.18 | 10.00 | 8.00 | |||
10852 | 50 | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 10 | 0.20 | 0.14 | 18.00 | 12.00 | |||
10853 | 50 | 35 | 9 | 1 | 0 | 0 | 0 | 0 | 45 | 0.90 | 0.72 | 34.00 | 24.00 | |||
10854 | 50 | 12 | 2 | 0 | 0 | 0 | 0 | 0 | 14 | 0.28 | 0.24 | 20.00 | 18.00 | |||
10855 | 50 | 17 | 5 | 0 | 0 | 0 | 0 | 0 | 22 | 0.44 | 0.34 | 30.00 | 22.00 | |||
10856 | 50 | 120 | 6 | 0 | 0 | 0 | 0 | 0 | 126 | 2.52 | 2.40 | 46.00 | 44.00 | |||
10857 | 50 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 6 | 0.12 | 0.08 | 12.00 | 8.00 | |||
Average | 34.0 | 4.0 | 0.5 | 0.1 | 0.1 | 0.0 | 0.0 | 38.8 | 0.78 | 0.69 | 25.00 | 20.75 | ||||
± SEM | 0.30 | 0.29 | 4.31 | 4.32 | ||||||||||||
Test Chemical | Ethyl acrylate |
225 |
10810 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 |
10811 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
10812 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10813 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
10814 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10815 | 50 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.06 | 4.00 | 4.00 | |||
10816 | 50 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.04 | 6.00 | 4.00 | |||
10817 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 10.00 | 8.00 | |||
Average | 1.5 | 0.6 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.1 | 0.04 | 0.03 | 4.00 | 2.75 | ||||
± SEM | 0.01 | 0.01 | 1.13 | 0.92 | ||||||||||||
Test Chemical | Ethyl acrylate |
450 |
10820 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 |
10821 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10822 | 50 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.04 | 8.00 | 4.00 | |||
10823 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10824 | 50 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.02 | 8.00 | 2.00 | |||
10825 | 50 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 0.16 | 0.16 | 10.00 | 10.00 | |||
10826 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10827 | 50 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.04 | 4.00 | 4.00 | |||
Average | 1.9 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.6 | 0.05 | 0.04 | 4.25 | 3.00 | ||||
± SEM | 0.02 | 0.02 | 1.44 | 1.20 | ||||||||||||
Test Chemical | Ethyl acrylate |
900 |
10830 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 |
10831 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10832 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10833 | 50 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0.08 | 0.08 | 8.00 | 8.00 | |||
10834 | 50 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.00 | 4.00 | 0.00 | |||
10835 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10836 | 50 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.00 | 2.00 | 0.00 | |||
10837 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
Average | 0.9 | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.4 | 0.03 | 0.02 | 2.75 | 1.75 | ||||
± SEM | 0.01 | 0.01 | 0.92 | 0.96 | ||||||||||||
Vehicle Control | No Stressor |
0 |
10840 | 50 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 |
10841 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10842 | 50 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0.04 | 0.02 | 4.00 | 2.00 | |||
10843 | 50 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0.10 | 0.08 | 6.00 | 6.00 | |||
10844 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | |||
10845 | 50 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 0.06 | 0.02 | 6.00 | 2.00 | |||
10846 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
10847 | 50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.02 | 0.02 | 2.00 | 2.00 | |||
Average | 1.1 | 0.8 | 0.1 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | 0.04 | 0.03 | 3.50 | 2.25 | ||||
± SEM | 0.01 | 0.01 | 0.82 | 0.59 | ||||||||||||
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation