| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02137-0016-0000-2 |
| Chemical Name: | Ethyl acrylate |
| CASRN: | 140-88-5 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 272157_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/10/1990 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11410 | 25 | 2.79 | ± | 0.367 |
| 11411 | 25 | 6.40 | ± | 0.704 | |||
| 11412 | 25 | 3.94 | ± | 0.481 | |||
| 11413 | 25 | 5.44 | ± | 0.532 | |||
| Average | 4.65 | ± | 0.799 | ||||
| Test Chemical | Ethyl acrylate |
225 |
11380 | 25 | 5.05 | ± | 0.523 |
| 11381 | 25 | 4.15 | ± | 0.507 | |||
| 11382 | 25 | 3.53 | ± | 0.432 | |||
| 11383 | 25 | 5.96 | ± | 0.612 | |||
| Average | 4.68 | ± | 0.530 | ||||
| Test Chemical | Ethyl acrylate |
450 |
11385 | 25 | 7.99 | ± | 0.619 |
| 11386 | 25 | 4.17 | ± | 0.383 | |||
| 11387 | 25 | 3.29 | ± | 0.274 | |||
| 11388 | 25 | 3.48 | ± | 0.284 | |||
| Average | 4.72 | ± | 1.103 | ||||
| Test Chemical | Ethyl acrylate |
900 |
11390 | 25 | 3.49 | ± | 0.507 |
| 11391 | 25 | 2.41 | ± | 0.431 | |||
| 11392 | 25 | 5.11 | ± | 0.745 | |||
| 11393 | 25 | 3.90 | ± | 0.320 | |||
| Average | 3.73 | ± | 0.558 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11415 | 25 | 9.41 | ± | 0.711 |
| 11416 | 25 | 10.13 | ± | 0.837 | |||
| 11417 | 25 | 7.78 | ± | 0.824 | |||
| 11418 | 25 | 7.13 | ± | 0.729 | |||
| Average | 8.61 | ± | 0.696 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed