COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0013-0000-3
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 295893_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/01/1986 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
 0.5       
 4816 50 7 2 0 0 0 0 1 10 0.20 0.16 16.00 12.00
    4817 50 6 3 0 0 0 0 0 9 0.18 0.12 18.00 12.00
    4818 50 10 0 0 0 0 0 0 10 0.20 0.20 18.00 18.00
    4819 50 2 8 0 0 0 0 0 10 0.20 0.04 10.00 6.00
    4820 50 20 31 5 4 0 0 1 61 1.22 0.52 28.00 16.00
    4821 50 14 8 2 3 0 0 0 27 0.54 0.32 26.00 20.00
    4822 50 8 3 0 0 0 0 0 11 0.22 0.16 16.00 12.00
    4823 50 9 1 0 0 0 0 0 10 0.20 0.18 18.00 14.00
Average         9.5 7.0 0.9 0.9 0.0 0.0 0.3 18.5 0.37 0.21 18.75 13.75
± SEM                         0.13 0.05 2.03 1.53
 
Test Chemical C.I. Acid orange 10 
550         
 4776 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4777 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    4778 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4779 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    4780 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    4781 50 1 1 1 0 0 0 0 3 0.06 0.04 4.00 4.00
    4782 50 3 1 2 0 0 0 0 6 0.12 0.10 4.00 4.00
    4783 50 3 4 3 2 0 0 0 12 0.24 0.12 8.00 6.00
Average         2.5 0.9 0.8 0.3 0.0 0.0 0.0 4.4 0.09 0.07 5.50 5.00
± SEM                         0.02 0.01 0.82 0.65
 
Test Chemical C.I. Acid orange 10 
1100         
 4786 50 2 0 0 0 0 0 1 3 0.06 0.06 6.00 6.00
    4787 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    4788 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    4789 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    4790 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4791 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    4792 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4793 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         1.4 0.6 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.03 3.25 2.50
± SEM                         0.01 0.01 0.65 0.91
 
Test Chemical C.I. Acid orange 10 
2200         
 4796 50 3 3 0 0 0 0 0 6 0.12 0.06 10.00 6.00
    4797 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    4798 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 4.00
    4799 50 12 2 0 0 0 0 0 14 0.28 0.24 16.00 14.00
    4800 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    4801 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    4802 50 2 1 0 1 0 0 0 4 0.08 0.04 8.00 4.00
    4803 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         3.1 1.4 0.0 0.1 0.0 0.0 0.0 4.6 0.09 0.06 7.25 4.75
± SEM                         0.03 0.03 1.64 1.51
 
Vehicle Control No Stressor 
 0         
 4806 50 0 1 0 2 0 0 0 3 0.06 0.00 4.00 0.00
    4807 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    4808 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    4809 50 2 1 0 0 0 0 0 3 0.06 0.04 4.00 2.00
    4810 50 3 2 0 0 0 0 0 5 0.10 0.06 6.00 4.00
    4811 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    4812 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    4813 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
Average         1.8 1.3 0.0 0.3 0.0 0.0 0.0 3.3 0.07 0.04 5.00 2.75
± SEM                         0.01 0.01 0.65 0.92
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation