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Study Information
Study Attribute Value
CEBS Accession Number: 002-01763-0013-0000-3
Chemical Name: C.I. Acid orange 10
CASRN: 1936-15-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 295893_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
01/09/1990 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 10755 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10756 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    10757 50 12 2 1 0 0 0 0 15 0.30 0.26 16.00 14.00
    10758 50 8 1 0 0 0 0 0 9 0.18 0.16 14.00 12.00
    10759 50 6 6 0 0 0 0 0 12 0.24 0.12 20.00 10.00
    10760 50 4 1 1 0 0 0 0 6 0.12 0.10 12.00 10.00
    10761 50 2 0 1 0 0 0 0 3 0.06 0.06 6.00 6.00
    10762 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
Average         5.0 1.6 0.4 0.0 0.0 0.0 0.0 7.0 0.14 0.11 11.00 8.25
± SEM                         0.03 0.03 1.89 1.33
 
Test Chemical C.I. Acid orange 10 
550         
 10715 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10716 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10717 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    10718 50 1 0 0 1 0 0 0 2 0.04 0.02 4.00 2.00
    10719 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10720 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10721 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10722 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         0.6 0.6 0.0 0.1 0.0 0.0 0.0 1.4 0.03 0.01 2.75 1.25
± SEM                         0.01 0.01 1.06 0.53
 
Test Chemical C.I. Acid orange 10 
1100         
 10725 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    10726 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10727 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10728 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10729 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10730 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10731 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    10732 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
Average         0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.01 1.75 1.00
± SEM                         0.01 0.01 0.70 0.53
 
Test Chemical C.I. Acid orange 10 
2200         
 10735 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10736 50 1 0 1 0 0 0 0 2 0.04 0.04 4.00 4.00
    10737 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    10738 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10739 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10740 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    10741 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10742 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.5 0.6 0.1 0.0 0.0 0.0 0.0 1.3 0.03 0.01 2.00 1.25
± SEM                         0.01 0.01 0.38 0.53
 
Vehicle Control No Stressor 
 0         
 10745 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10746 50 2 0 0 0 0 0 0 2 0.04 0.04 2.00 2.00
    10747 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    10748 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    10750 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10751 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    10752 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    10753 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.9 0.3 0.0 0.0 0.0 0.0 0.0 1.1 0.02 0.02 2.00 1.50
± SEM                         0.01 0.01 0.65 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation