| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01763-0012-0000-2 |
| Chemical Name: | C.I. Acid orange 10 |
| CASRN: | 1936-15-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 295893_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 09/04/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
4176 | 25 | 4.73 | ± | 1.177 |
| 4177 | 25 | 4.29 | ± | 0.481 | |||
| 4178 | 25 | 5.21 | ± | 0.614 | |||
| 4179 | 25 | 4.54 | ± | 0.269 | |||
| Average | 4.47 | ± | 0.194 | ||||
| Test Chemical | C.I. Acid orange 10 |
550 |
4151 | 25 | 5.33 | ± | 0.464 |
| 4152 | 25 | 6.12 | ± | 0.542 | |||
| 4153 | 25 | 4.72 | ± | 0.489 | |||
| 4154 | 25 | 3.60 | ± | 0.436 | |||
| Average | 4.94 | ± | 0.531 | ||||
| Test Chemical | C.I. Acid orange 10 |
1100 |
4146 | 25 | 5.13 | ± | 0.782 |
| 4147 | 25 | 3.61 | ± | 0.384 | |||
| 4148 | 25 | 4.47 | ± | 0.448 | |||
| 4149 | 25 | 4.70 | ± | 0.590 | |||
| Average | 4.47 | ± | 0.319 | ||||
| Test Chemical | C.I. Acid orange 10 |
2200 |
4141 | 25 | 5.41 | ± | 0.689 |
| 4142 | 25 | 6.72 | ± | 0.687 | |||
| 4143 | 25 | 5.18 | ± | 0.614 | |||
| 4144 | 25 | 5.65 | ± | 0.572 | |||
| Average | 5.75 | ± | 0.341 | ||||
| Positive Control | Mitomycin-C |
0.5 |
4171 | 25 | 8.36 | ± | 0.847 |
| 4172 | 25 | 6.83 | ± | 0.575 | |||
| 4173 | 25 | 6.36 | ± | 0.585 | |||
| 4174 | 25 | 5.32 | ± | 0.354 | |||
| Average | 6.72 | ± | 0.631 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed