| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01763-0012-0000-2 |
| Chemical Name: | C.I. Acid orange 10 |
| CASRN: | 1936-15-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 295893_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 08/01/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8558 | 25 | 2.96 | ± | 0.313 |
| 8559 | 25 | 5.54 | ± | 0.640 | |||
| 8560 | 25 | 4.76 | ± | 0.661 | |||
| 8561 | 25 | 3.72 | ± | 0.402 | |||
| Average | 4.25 | ± | 0.568 | ||||
| Test Chemical | C.I. Acid orange 10 |
1650 |
8548 | 25 | 9.62 | ± | 0.979 |
| 8550 | 25 | 7.45 | ± | 0.900 | |||
| 8551 | 25 | 10.60 | ± | 0.982 | |||
| 8552 | 25 | 7.09 | ± | 0.632 | |||
| Average | 8.69 | ± | 0.848 | ||||
| Test Chemical | C.I. Acid orange 10 |
2200 |
8553 | 25 | 7.45 | ± | 0.990 |
| 8554 | 25 | 7.52 | ± | 1.132 | |||
| 8555 | 25 | 6.82 | ± | 0.967 | |||
| 8556 | 25 | 6.88 | ± | 0.874 | |||
| Average | 7.18 | ± | 0.185 | ||||
| Positive Control | Mitomycin-C |
1 |
8563 | 25 | 6.76 | ± | 0.698 |
| 8564 | 25 | 7.06 | ± | 0.579 | |||
| 8565 | 25 | 6.92 | ± | 0.624 | |||
| 8566 | 25 | 6.28 | ± | 0.430 | |||
| Average | 6.76 | ± | 0.169 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed